RECOL RECOL ZOCOR ZOCOR ZOCOR SIMVA SIMVA SIMVA SIMVA LIMITROL LIMITROL LIMITROL LIPIX LIPIX SURVIVE SURVIVE NEUTRACHOL NEUTRACHOL NEUTRACHOL SIMVACOR SIMVACOR SIMVACOR SAISTA SAISTA SAISTA LIPOMED LIPOMED LIPOSTAT LIPOSTAT LIPOSTAT VASTIN VASTIN CR-10 SICHOR SICHOR MAVEST MAVEST SIMVASCOT SIMVASCOT SIMWIN SIMWIN SMARTIN SMARTIN SILSER SILSER SIMVAZAF SIMVAZAF ATCOL ATCOL SIMATIN SIMATIN MACQUISTEN MACQUISTEN EGLOCARD EGLOCARD EGLOCARD EGLOCARD SIMCAM SIMCAM COLOCARD COLOCARD SURVASTIN SURVASTIN SIVASTIN SIVASTIN LIPONORM LIPONORM LIPONORM SIMPLACOR SIMPLACOR SIMVASTIN SIMVASTIN LOKESTROL ANTICHOL ANTICHOL LIPAXIN LIPAXIN LIPAXIN SIM-STAT SIM-STAT CARVES CARVES OBVASTIN SIMTAS SIMTAS CARDIOVASTIN CARDIOVASTIN SIMS SIMS SIMPILL SIMPILL VANPIN ROZOC ROZOC ROZOC ATHENIL ATHENIL ATHENIL MODLIP MODLIP MODLIP MODLIP LIPOLO LIPOLO NOVICOR NOVICOR SIMOLIVE SIMOLIVE FATRID FATRID VIMTIN VIMTIN FASTATIN FASTATIN SIMCOR SIMCOR SAMAN SAMAN EUCOR EUCOR BESTATIN SIM-STILL SIM-STILL SURVITROL-S SURVITROL-S CHEMSLIM CHEMSLIM SIMPID NEOCOM S NEOCOM SD NEOCOM SD SIMLO SIVINAR SLIMSTATIN SLIMSTATIN LIPLOW LIPLOW SIMIB SIMB FORTE SIMBEX NUISTA PLUS EZCHOL EZCHOL LIPINIL LIPINIL LOPOIDCOR MAVIK MEDIVASTIN MEDIVASTIN NUISTA NUISTA NUISTA RACOR RACOR LIMITROL EZ LIMITROL EZ MODLIP Z MODLIP Z MODLIP Z MODLIP Z ZOSURE ZOSURE ROCOZ SYNIMAX SYNIMAX SIMEZET SIMEZET SIMEZET BEVESTIN SAVASTIN SAVASTIN SAVASTIN SIMLIP SIMLIP SISTIN SISTIN WASTATIN SIMVA PLUS SIMVA PLUS SIMVA PLUS ATROCARD ATROCARD ATROCARD VESTAR VESTAR VESTAR ZEYVIST ZEYVIST HYSIN-E HYSIN-E HYSIN-E HYSIN-E IRIL IRIL IRIL IRIL IRIL IRIL IRIL IRIL IRIL IRIL IRIL IRIL IRIL RASIMET RASIMET RASIMET RASIMET SIM-EZEE SIM-EZEE SIM-EZEE SIM-EZEE TAVAM TAVAM TAVAM ZESHOL ZESHOL ZESHOL NEUTRACHOL PLUS NEUTRACHOL PLUS NEUTRACHOL PLUS NEUTRACHOL PLUS NEUTRACHOL PLUS NEUTRACHOL PLUS NEUTRACHOL PLUS NEUTRACHOL PLUS L-COL L-COL NEOLIP NEOLIP SURVIVE PLUS SURVIVE PLUS SURVIVE PLUS SIMVOGET CRUDIN CRUDIN SIMTROL EZETIN EZETIN EZETIN EZETIN

Dose: 5 to 80 mg
Single Dose: 42 (42.5)
Frequency: 24 hourly
Route: PO
Instructions: In evening, maintenance dose ranges 5-40 mg.

Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group

Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group

Simvastatin also known as Synvinolin. . It is of Synthetic origin and belongs to Lactone. It belongs to HMGCoA reductase inhibitor pharmacological group on the basis of mechanism of action and also classified in Antilipemic Agent pharmacological group.The Molecular Weight of Simvastatin is 418.60.

Simvastatin is contraindicated in conditions like Hyperlipidemia,Familial hypercholesterolaemia,Hypersensitivity,Acute liver disease,Porphyria.

The severe or irreversible adverse effects of Simvastatin, which give rise to further complications include Acute renal failure.The symptomatic adverse reactions produced by Simvastatin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Headache, Fatigue, Nausea, Diarrhea, Constipation, Abdominal pain, Elevation of liver enzymes, Myopathy, Rhabdomyolysis, Muscle tenderness, Increased intracranial pressure, Hepatitis, Pancreatitis.

Simvastatin is primarily indicated in conditions like Atherosclerosis, Combined hyperlipidaemia, Coronary heart disease, Elevated plasma cholesterol levels, Homozygous familial hypercholesterolemia, Hypercholesterolaemia, Induction and maintenance of anaesthesia, Myocardial infarction prophylaxis, NSAID-associated gastric and duodenal ulcers (prophylaxis).

Simvastatin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAmiodarone (HCl)Increased risk of myopathy when amiodarone is given with simvastatin. MajorAvoid doses of simvastatin above 20 mg daily.AmprenavirAmprenavir possibly increases plasma concentration of Simvastatin. ADVICE: Avoid concomitant use.MajorAtazanavirAtazanavir inhibits the hepatic metabolism of simvastatin results in increased plasma concentration.MajorThis combination is considered contraindicated. Patient should notify to physician if experience unexplained muscle pain, tenderness, or weakness, malaise or fever. Discontinue therapy if level of creatinine kinase is increased or if myopathy diagnosed.BosentanBosentan possibly reduces plasma concentration of Simvastatin.CiprofibrateColestipol (HCl)DanazolConcomitant administeration can lead to RhabdomyolysisDigoxinConcomitant administerationn can slightly increase in digoxin levelItraconazoleKetoconazoleLinagliptin10 mg of Linagliptin increases AUC by 34% and Cmax by 10% of simvastatin (40 mg)Mibefradil (Di HCl)TelithromycinSimvastatin levels were increased by Teicoplanin when used concurrently.Ticagrelorsimvastatin is metabolised by CYP3A4 engzyme ( other e.g; Atorvastatin ) so ticagrelor may increase cmax of simvastatin by 81%, AUC 56%dose of Atorvastatin, symvastatin should be less than 40mg, greater than 40mg is not recommendedTocilizumabToclizumab decreases exposure of simvastatinVORICONAZOLEVoriconazole may increase the serum concentration of simvastatin by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects Warfarin (Na)Simvastatin may enhance the anticoagulant effect of Warfarin. Moderate (Sequence important)Monitor for increased effects of Warfarin if Simvastatin is initiated/dose increased, or decreased effects if Simvastatin is discontinued/dose decreased. Dosage adjustments of Warfarin may be needed. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Increased Alkaline Phosphatase LevelsElevaions in creatinine phosphokinase levels

Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Tab Store Below 40°C. Protect from Sunlight and Moisture.

Use simvastatin with caution in patients with liver disease, severe infection, kidney disease, heart disease, hypothyroidism, history of alcoholism or any allergy, especially drug allergies. Limit alcohol intake as it may aggravate side effects. Simvastatin should not be used during pregnancy or lactation.