Silver Sulphadiazine

Silver Sulphadiazine is a topical anti-infective agent with the antibacterial properties of both silver ion and sulfadiazine. Both free silver and the sulfonamide moiety may exert activity, Silver Sulphadiazine is used to prevent and treat infections of wounds caused by second- and third-degree burns. The drug does not inhibit folic acid synthesis as other sulfonamides do, rather disrupts bacteria by damaging the cell membrane and the cell wall. It has a wide spectrum of bactericidal activity against both gram-positive and gram-negative organisms.


Adult Dose
Dose: 1%
Single Dose: 1 (1)
Frequency: As recommended.
Route: Topical
Instructions: As Required
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose: 1%
Single Dose: 1 (1)
Frequency: As recommended.
Route: Topical
Instructions: As Required . For above 3 yrs of children
Characteristics
. It is of Synthetic origin and belongs to Sulphonamide. It belongs to Antibiotics, Other pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Topical pharmacological group.The Molecular Weight of Silver Sulphadiazine is 357.10.
Contraindications
Silver Sulphadiazine is contraindicated in conditions like Pregnancy,Hypersensitivity to any component of product.
Effects
The severe or irreversible adverse effects of Silver Sulphadiazine, which give rise to further complications include Nephrotic syndrome, Leucopenia, Glomerulonephritis.The symptomatic adverse reactions produced by Silver Sulphadiazine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Skin rashes.
Indications
Silver Sulphadiazine is primarily indicated in conditions like Bacterial infections, Burns and scalds, Infections, Wounds.
Interactions
Silver Sulphadiazine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementPovidone-IodineConcomitant administration of silver sulfadiazine may possibly result in partial inactivation.Sulfacetamide SodiumTopical sulfonamides are incompatible with silver salts.Concurrent use is not recommended.TolbutamideTrimethoprim These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Cream Store at room temperature. Do not Freeze.
Warnings
Use silver sulfadiazine with caution in patients with any allergic reaction to any "sulfa" drug and if have liver or kidney disease. Use silver sulfadiazine with caution during pregnancy.
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