Albuterol

Salbutamol/Albuterol is a beta receptor agonist. Salbutamol is a short acting agent and is used only in the managment of acute episode of asthma. It relaxes the smooth muscle in the lungs and dilates or expands the bronchi (air ways) in lungs and makes breathing easy.


Brands
BRONKAL RESPIRATOR BRONKAL BRONKAL BRONKAL BLISS BRONCAL SALBANOL BREATH EXPECTORANT CLENIL COMPOSITUM INHALER CLENIL COMPOSITUM-A BUTOVENT ASTHAMOL-2 ASTHAMOL-2 ASTHAMOL-2 ASTHAMOL-4 ASTHAMOL-4 ASTHAMOL-4 ASTHAMOL ASTHAMOL BUTOSOL BUTO-ASMA VENTIDE VENTOLIN EXPECTORANT VENTOLIN VENTOLIN VENTOLIN VENTOLIN VENTOLIN VENTOLIN VENTOLIN VENTOLIN AEROLIN EVOHALER BRONCOLIN BRONCOLIN BRONCOLIN BRONCOLIN XALTIDE SALBO SALBO IPRATEC-S AEROTEC-B AEROTEC-B FORTE GENMOL GENMOL GENMOL BUTAMOL-E BUTAMOL BUTAMOL BUTAMOL SALNON INSPIROL VENTOMED VENTOMED BRETHEEZ-E BRETHEEZ PESPOLIN BUTAMIN BUTAMIN BUTAMIN BUTAMIN FAKTOLIN FAKTOLIN FAKTOLIN FAKTOLIN FAKTOLIN FAKTOLIN FAKTOLIN VENEX AEROSOL VENEX AEROSOL VENEX AEROSOL VENEX AEROSOL SALMAX SALBEST CFC TEXCOL-E TEXCOL-E SALBULIN ASMATOL ASMATOL EULIN EULIN BRONCHOTAB BRONCHOTAB BRONCHOTAB BRONCHOTAB ZAFTOLIN ZAFTOLIN ZAFTOLIN ZAFTOLIN ZAFTOLIN BECLO SAL RESPIRATE-E RESPIRATE RESPIRATE VENTOMOL VENTOMOL VENTOMOL VENTOMOL SALVUTOL SALVUTOL SALVUTOL SALVUTOL SALVUTOL INHALERIN INHALERIN INHALERIN INHALERIN SALBONIL VENTROL AEROLIN AEROLIN AEROLIN AEROLIN AEROLIN AEROLIN AEROLIN DECTAMOL HONEX HONEX RENTOLIN RENTOLIN RENTOLIN BRANKOSOL EROBOLIN DS EROBOLIN DS EROBOLIN DS EROBOLIN EROBOLIN EROBOLIN EROBOLIN EROBOLIN ERBOLIN ERBOLIN ERBOLIN ERBOLIN ASALKAR ASALKAR ASALKAR RESPILAX RESPILAX RESPILAX RESPILAX RESPILAX SALBUTAMOL VENTEZE VENTEZE VENTEZE EXPECTUM SALAMOL BRONCOREX BRONCOREX BRONCOREX SALCOL SALBUVENT EXP SALBUVENT SALBUVENT SALBUVENT VINBULIN VINBULIN VINBULIN VINBULIN SALBOCARE PULMOX E TACSOL GABTOL PULMOX-S SALBITAL SALBITAL SALBUGREEN SALBUGREEN SALBUGREEN MYMOL VENTUM-E BRONCHILATE BRONCHILATE BRONCHILATE TOLIN ASTHAMIN EZIBREATH ASTHASIM
Adult Dose
Dose: 2.5 to 5 mg
Single Dose: 3.8 (3.75)
Frequency: 6 hourly
Route: Inhalation
Instructions: To be used with nebuliser or respirator
Neonatal
Dose: 0.156 mg/kg
Single Dose: 0.16 (0.156)
Frequency: 6 hourly
Route: Inhalation
Instructions: Via nebulizer
Paedriatic
Dose: 0.25 mg/kg
Single Dose: 0.25 (0.25)
Frequency: 6 hourly
Route: Inhalation
Instructions: Recommended via Nebulization
Characteristics
Albuterol also known as Salbutamol Sulphate. Salbutamol is the derivative of Albuterol. It is of Synthetic origin and belongs to Phenylbutylalcohol. It belongs to Beta-2 adrenergic agonist pharmacological group on the basis of mechanism of action and also classified in Bronchodilator pharmacological group.The Molecular Weight of Albuterol is 239.30. Its pKa is 9.3, 10.3.
Contraindications
Albuterol is contraindicated in conditions like Cardiac arrhythmia,Diabetes mellitus,Hypertension,Thyrotoxicosis,Ischaemic heart disease,Hypersensitivity,Antepartum haemorrhage,Toxaemia of pregnancy.
Effects
The severe or irreversible adverse effects of Albuterol, which give rise to further complications include Tachycardia, Hypokalemia, Sinus bradycardia, Ventricular ectopics, Peripheral vasodilatation.The signs and symptoms that are produced after the acute overdosage of Albuterol include Flushing, nervousness, Hypokalemia, Palpitations, CNS stimulation, Tremor, Agitation, Weakness.The symptomatic adverse reactions produced by Albuterol are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Vomiting, Anxiety, Palpitation, Tremor, Muscle cramps, Heart burn, Appetite stimulation.
Indications
Albuterol is primarily indicated in conditions like Asthma, Bronchitis, Bronchospasm, Emphysema, Exercise-induced bronchospasm, Reversible airways obstruction, and can also be given in adjunctive therapy as an alternative drug of choice in Premature labour.
Interactions
Albuterol is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAmiloride (HCl)Should not use concurrently without doctors prescription.Chlorothiazidehypokalemia may be enhanced by co adminstration of diruretcs such as chlorothiazide wtih salbutamol Should not use concurrently without doctors prescription.Digoxincoadministration of salbutamol with cardiac glycosides produce fall in plasma concentrations and decrease serum concentration of digoxinEphedrineShould not use concurrently without doctors prescription.FurazolidoneShould not use concurrently without doctors prescription.HydrochlorothiazideShould not use concurrently without doctors prescription.MetipranololInfrequent reports of METIPRANOLOL [EYE] reducing the BRONCHODILATOR effect of SALBUTAMOL. MajorPancuronium (Br)salbutamol enhace neuromuscular blockade produced by neuromuscular blockers e.g pancuronium and vecuroniumPhenelzineShould not use concurrently without doctors prescription.Propranolol (HCl)co administration of salbutamol with beta blockers such as propanolol, salmeterol , may have a additive effects to contro acute bronchospasm, reduce the sensitivity to salbutamolShould not use concurrently without doctors prescription.Pseudoephedrine (HCl)Should not use concurrently without doctors prescription.Selegiline (HCl)Should not use concurrently without doctors prescription.Spironolactonehypokalemia may be enhanced by co adminstration of diruretcs such as spironolactone Should not use concurrently without doctors prescription.TheophyllineAn enhanced hypokalemic effect may occur during co administration of salbutamol and theophylline Timolol (Maleate)Should not use concurrently without doctors prescription.Tranylcypromine (Sulphate)Should not use concurrently without doctors prescription. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inhaler Store at room temperature. Protect from Sunlight and Heat. Syrup, Inj Store at room temperature, Below 30°C or in refrigerator. Do not Freeze. Protect from Sunlight. Tab Store in a well closed container, at room temperature, Below 30°C or in refrigerator. Do not Freeze. Protect from Heat.
Warnings
The management of asthma should normally follow a stepwise program, and patient response should be monitored clinically and by lung function test. In patients who are considered at risk, daily peak flow monitoring may be instituted. Salbutamol should be used with caution in patients with hyperthyroidism, myocardial insufficiency, arrhythmias, hypertension and diabetes mellitus. It should be used with caution during pregnancy.
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