Dose: 0.71 to 1.43 ug/kg
Single Dose: 1.1 (1.07)
Frequency: 24 hourly
Route: PO
Instructions: Maintenance

Dose: Not indicated in children
Single Dose:
Frequency:
Route:
Instructions:

. It is of Natural origin and belongs to Alkaloid. It belongs to Amine depletion pharmacological group on the basis of mechanism of action and also classified in Antihypertensive Agents pharmacological group.The Molecular Weight of Rauwolfia Reserpine is 608.70. Its pKa is 6.6.

Rauwolfia Reserpine is contraindicated in conditions like Asthma,Depression,Peptic ulcer,Renal failure,Bronchitis.

The severe or irreversible adverse effects of Rauwolfia Reserpine, which give rise to further complications include Congestive heart failure, Bronchospasm, Dyskinesias, Parkinsonism, Dystonia.Rauwolfia Reserpine produces potentially life-threatening effects which include Depression of CNS, Angioimmunoblastic lymphadenopathy. which are responsible for the discontinuation of Rauwolfia Reserpine therapy.The signs and symptoms that are produced after the acute overdosage of Rauwolfia Reserpine include Bradycardia, Bronchospasm, Coma, Unconsciousness, Respiratory depression, Hypothermia, Tremor, Dystonic movements.The symptomatic adverse reactions produced by Rauwolfia Reserpine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Loose stools, Drowsiness, Restlessness, Impotence, Sleep disturbance, Weight gain, Loss of libido, Nasal congestion, Fluid retention, Nightmares, Increased appetite, Galactorrhea, Menstrual irregularity, Increased intracranial pressure, Amenorrhea, Ocular palsies.

Rauwolfia Reserpine is primarily indicated in conditions like Agitation, Cerebrovascular accident, Hypertension, Hypertension in pregnancy, Hypertensive emergencies, Psychosis, and can also be given in adjunctive therapy as an alternative drug of choice in Peripheral vasospasm.

Rauwolfia Reserpine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholDigitoxinDigoxinDoxepin (HCl)EphedrineFenfluramine (HCl)Glyceryl TrinitrateHalothaneHalothaneLevodopaNefopam (HCl)Nortriptyline (HCl)Phenylephrine (HCl)QuinidineTranylcypromine (Sulphate)Trimipramine (Maleate) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Estimation of urinary Corticosteroids,17-hydroxycorticosteroids by Porter-Silber reaction. Estimation of 17-ketosteroids by interference with Zimmerman Reaction

Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Tab Store in a well closed container, Below 40°C. Protect from Sunlight.

Discontinue reserpine 7 days before electricshock. It should be used with caution in patients with history of peptic ulcer, gallstone, ulcerative colitis and renal (kidney) insufficiency.