Pseudoephedrine (HCl)

Pseudoephedrine (HCl) is a sympathomimetic agent, closely related to ephedrine. Pseudoephedrine (HCl) is used in various cough and cold preparations as a nasal decongestant, provides relief from the nasal or sinus congestion.


Brands
KOMKOLD KOMKOLD TELFAST-D FLUCOL FLUCOL TYLADOL-CF EPINOL-DM EPINOL-DM PABCOL PABCOL PABCOL PABDRYL PABDRYL PABDRYL AMMOFED AMMOFED AMMOFED ACTIFED-DM ACTIFED-DM ACTIFED-DM ACTIFED-P ACTIFED-P ACTIFED-P ZODEC ZODEC ARINAC ARINAC AMOLE POWER DEXODINE DEXODINE COSOME SANCOS SANCOS TRIAMINIC TRIAMINIC TRIAMINIC-DM TRIAMINIC-E ILLCO NOVATUS RELTUS C&F RELTUS C&F RELTUS-DM TEXCOL PLUS TEXCOL SINUS TEXCOL SINUS BENICAL PEDROL-CF SUDOMIN COLDENE TRIOCOF ADICOS-M ADICOS-M CONIL CONIL CONIL NEOPHED-P DCOLD DCOLD KOFNIL KOFNIL KOMKOLD-DM KOMKOLD-DM ACFIN-P COLDREX DOSAFED-P DOSAFED-P C.C. DON-CF UNEXOFED DM FLUNEC-D FLUNIL FLUNIL FLUNIL PANADOL-CF DOSAFED-DM DELMOL-CF TRIOCOF-SF CO-EAS CO-EAS FEDRIN FEDRIN KIDICOLD NENGESIC-CF RUNIK BENYLIN-E DAYCOR NICOR RHINOFF RONDEC-D RONDEC-TR REGOFID-DM REGOFID-DM REGOFID-DM REGOFID-P REGOFID-P REGOFID-P CLARINASE REPETABS PROLIFED-P RHINOFF FORTE RESIDOL-CF TRIAMINIC COUGH (CHILD) TRIAMINIC COLD & ALLERGY ARINAC FORTE KOFNIL-D KOFNIL-D TRIAMINIC CHEST FEXO-D EPINOL-CF EPINOL-CF RUNIK FORTE FEDRIN FORTE PANAFIN-CF NEONAC RHILOR D FENMOL CF FLUCARE FLU-FINE FLU-FINE VISCODIN TRIPLON-P TRIPLON-N COLLERGY RELTUS C&F PLUS NOCONGEST ARINAC BLISTER FLU-P ROYACOF CUFGO DM FLUREST COFCINA-D COFCINA-D RHENONILL FORTE TRIAMINIC FLUE,COUGH FLUFREE TELFEX-D RESINAC RESINAC FORTE FRINAC LORTIN-P PULMAX PULMAX REMAST-P SENSI E TORAX-G CAFIMOL CF SEDOFEN-FORTE SEDOFEN-P SUDOFIN SUDOFIN DENOL-DM AXODINE-D HANMOL CF GRAYPYRINE FENADRIN D FEXOTA PLUS NIGHTEZE NIGHTEZE FEXET D MULTI-ACTION MULTI-ACTION NOVADIN NOVADIN FLUTAB FLUTAB FLUTAB SINURINE FORTE SINURINE FORTE CHILMINIC FENDINA D IRZAPOLE CF JETAMOL CF LISKOFID-P IBURIN PLUS REDUCE ACHE TANDEGYL D DEKOF REGODIL REGODIL REGODIL SIZZLE D BRIGIDA QUINCE FEXOFIN ZIXANT ALOC D DELSYM NASCOL NASCOL BENAFED CF FEXOFIN D FLULIVE FASTEC-D PESUDOMOL PESUDOMOL PESUDOMOL FORT COFCARE COMBINOL DM COUGH DESRHIN DESRHIN ENAC GENFIX-D KARMOL CF PROPHED PROPHED FORTE PROPHED FORTE PSEUDOEPHEDRINE REGODOL CF REGOFAST D EVASTIN-D ROVINAC ROVINAC X-PAN ROVINAC FORTE CHILPOL CF AVALON FLU EPLACIN CF FANASEL PLUS GERILINE MASTAL PLUS NOVAHIST-D NOVAHIST-D TYLOL CF WYLADOL-CF BRONCOS DM COFCOLD DM DAGNUM COUGH KARMOL-NEO VIODOL CF FENOXIN CF REDUCE ACHE FORTE NOCOF COLD-EEZE
Adult Dose
Dose: 60 to 240 mg
Single Dose: 150 (150)
Frequency: 4 hourly
Route: PO
Instructions:
Neonatal
Dose: 0.625 to 1.875 mg/kg
Single Dose: 1.2 (1.25)
Frequency: 8 hourly
Route: Oral
Instructions:
Paedriatic
Dose: 1.5 mg/kg
Single Dose: 1.5 (1.5)
Frequency: 8 hourly
Route: Oral
Instructions: -
Characteristics
Pseudoephedrine, Pseudoephedrine are the derivatives of Pseudoephedrine (HCl). It is of Natural origin and belongs to Alkaloid. It belongs to Alpha & Beta adrenergic agonist pharmacological group on the basis of mechanism of action and also classified in Nasal Decongestants pharmacological group.The Molecular Weight of Pseudoephedrine (HCl) is 201.70. Its pKa is 9.22.
Contraindications
Pseudoephedrine (HCl) is contraindicated in conditions like Diabetes mellitus,Hypertension,Hyperthyroidism,Prostatic hypertrophy,Cardiovascular disease,Endocrine disorder.
Effects
Pseudoephedrine (HCl) produces potentially life-threatening effects which include Hypertension, Unconsciousness. which are responsible for the discontinuation of Pseudoephedrine (HCl) therapy.The signs and symptoms that are produced after the acute overdosage of Pseudoephedrine (HCl) include Tachycardia, Hallucinations, Restlessness, Excitation, Hyperreflexia, Rapid Speech, Hypertonicity, Pupillary dilatation.The symptomatic adverse reactions produced by Pseudoephedrine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Drowsiness, Anorexia, Anxiety, Restlessness, Insomnia, Sleep disturbancesX, Dry mouth, Tremor.
Indications
Pseudoephedrine (HCl) is primarily indicated in conditions like Bronchospasm, Nasal congestion, Rhinitis, Upper respiratory tract infections.
Interactions
Pseudoephedrine (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAdrenalineAlbuterolShould not use concurrently without doctors prescription.Aluminium Hydroxide and Oxidealuminium hydroxide incerases the absorbtion of Pseudoephedrine (HCl)FurazolidoneBoth agents act synergistically affecting the sympathomimetic activity in this way that furazolidone enhances the storage of norepinephrine in adrenergic neuron and pseudoephedrine increases its liberation result in severe hypertension and hyperpyrexia.MajorBoth agents should not be used in combination.There should be gap of atleast 14 days before initiation of pseudoephedrine therapy and discontinuation of therapy with furazolidone.IsocarboxazidLinezolidMethyldopaMethyldopa and resperpine increase the afficacy of Pseduoephedrine (HCl)MoclobemideMoclobemide results in hypertensive crisis with Pseudoephedrine (HCl)NitroglycerinPseudoephedrine (HCl) oppose the vasodilatory actions of nitroglycerin and may cause angina. OxytocinPromethazine (HCl)QuinidineSibutramineSodium AcetateAlkalization of the urine decreases the urinary excretion increases the elimination half-life of Pseudoephedrine (HCl). According to one report, an increase in pH from 5.1 to 7.1 increased the half-life of pseudoephedrine from 5 to 16 hours. Toxicity from long-term use of pseudoephedrine has been demonstrated in patients with persistently alkaline urine.ModeratePatients should be monitored for toxic effects such as tremor, anxiety, insomnia, irritability, or nervousness. Dosage reductions may be required.Sodium BicarbonateTranylcypromine (Sulphate) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Syrup Store in a well closed container, Below 30°C. Do not Freeze. Protect from Sunlight. Tab Store in a well closed container, Below 40°C. Protect from Sunlight.
Warnings
Although pseudoephedrine has no significant pressure effect in normotensive patients, It should be used with caution in the patient with hypertension, patients using tricyclic antidepressants, decongestant, appetite suppressants and amphetamine like psychostimulants. Particular care should also be taken in treating patient with underlyning diseases associated with autonomic dysfunction, such as long standing insulin-dependent diabetes mellitus or thyroid disease. Other conditions also exacerbated by pseudoephedrine include myocardial ischmia, cardiac arrhythmia, glucoma, and urinary retension. Do not take the drug more than seven days. Use with great caution in the presence of liver or the kidney impairment. Use topical decongestant (pseudoephedrine) only in acute conditions, not longer than 3 to 5 days. It should be used sparingly in all patients, especially in infants, children and in cardiac patients. Patient should not derive or operate machinery until they have determined their own response. Concomitant use of alcohol or other centrally acting sedative should be avoided. not to be used in nursing mother. Not to be used in patient MAOI inhibitors.
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