Dose: 0.07 to 0.19 mg/kg
Single Dose: 0.13 (0.13)
Frequency: 8 hourly
Route: PO
Instructions: -

Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group

. It is of Synthetic origin and belongs to Tricyclic Propylamine. It belongs to Amine uptake inhibitor pharmacological group on the basis of mechanism of action and also classified in Psychotherapeutic Drugs and Antidepressant pharmacological group.The Molecular Weight of Protriptyline (HCl) is 299.80.

Protriptyline (HCl) is contraindicated in conditions like Cardiac arrhythmia,Myocardial infarction,Heart block.

The severe or irreversible adverse effects of Protriptyline (HCl), which give rise to further complications include Ataxia, Confusion, Drowsiness, Peripheral neuropathy, Extrapyramidal symptoms, Numbness, Paresthesia, Dizziness, Disorientation, Nightmares, Fatigue.Protriptyline (HCl) produces potentially life-threatening effects which include Mania, Worsening of psychosis. which are responsible for the discontinuation of Protriptyline (HCl) therapy.The signs and symptoms that are produced after the acute overdosage of Protriptyline (HCl) include Tachycardia, Coma, Drowsiness, Fever, Stupor.The symptomatic adverse reactions produced by Protriptyline (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Constipation, Dry mouth, Blurred vision, Urinary retensionX, Mydriasis, Hyperhidrosis.

Protriptyline (HCl) is primarily indicated in conditions like Depression.

Protriptyline (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAdrenalineAlcoholAstemizoleCimetidine (HCl)Clonidine (HCl)GuanethidineHaloperidolNoradrenaline (Acid Tartrate)Sotalol (HCl)VORICONAZOLEAdditive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

None well documented

Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Tab Store Below 40°C. Protect from Sunlight and Moisture.

Protriptyline should be used with caution (if it contains tartrazine) in patients with aspirin hypersensitivity, because it may produce allergic reaction (including bronchial asthma). Monitor ECG before initiating large doses. Avoid concurrent administration with electric shock therapy because may increase the hazards of therapy. Perform periodic leukocytes (white blood cells) counts and liver function tests. Photosensitization may occur so caution patients to take protective measures, sunscreens e.t.c.against exposure to UV light or sun light.