Protamine (Sulphate)

Protamine is a heparin antagonst. Protamine (Sulphate) is a purified mixture of simple protein principles extracted from the sperm or testes of suitable species of fish, which has the property of neutralizing heparin. Protamine (Sulphate) is used as an antidote of heparin to inhibit the anticoagulant effect of heparin.

Brands
PROTAMINE SULPHATE PROTAMINE SULPHATE
Adult Dose
Dose: 2.5 to 5 mg.min
Single Dose: 3.8 (3.75)
Frequency: As recommended.
Route: IV Inf
Instructions: For 10 Minutes
Neonatal
Dose: IV Infusion
Single Dose: As per Heparin Dosage
Frequency:
Route:
Instructions:
Paedriatic
Dose: IV Infusion
Single Dose: As per Heparin Dosage
Frequency:
Route:
Instructions:
Characteristics
. It is of Natural origin and belongs to Protein. It belongs to Blood Coagulation pharmacological group on the basis of mechanism of action and also classified in Antidotes pharmacological group.The Molecular Weight of Protamine (Sulphate) is 4500.00.
Contraindications
Protamine (Sulphate) is contraindicated in conditions like Hypersensitivity to any component of product.
Effects
Protamine (Sulphate) produces potentially life-threatening effects which include Anaphylaxis, Catastrophic pulmonary vasoconstriction. which are responsible for the discontinuation of Protamine (Sulphate) therapy.The symptomatic adverse reactions produced by Protamine (Sulphate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Urticaria, Bradycardia, Hypotension, Flushing, Warmth feeling.
Indications
Protamine (Sulphate) is primarily indicated in conditions like Heparin overdose.
Interactions
No data regarding the interactions of Protamine (Sulphate) was found.
Interfrence
Fluorescent method of estimating plasma catecholamines
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store in refrigerator. Do not Freeze.
Warnings
Do not administer protamine more than 100mg over a short period unless required because of the anticoagulant effect.
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