INDERAL INDERAL INDERAL INDERAL-LA OPRINOL OPRINOL BETABLOCK BETABLOCK BETANOL BETANOL PROPRANOLOL HCL PROPRANOLOL HCL CARDINOL CARDINOL BLOCKONOL BLOCKONOL HYPORIDE-LA BLOKONOL BLOKONOL OPINOL OPINOL PROPANOL PROPANOL PROPRANOLOL CARDIOSET CARDIOSET CARA-PROP CARA-PROP CARA-PROP CARA-PROP

Dose: 10 to 40 mg
Single Dose: 25 (25)
Frequency: 8 hourly
Route: PO
Instructions:

Dose: 0.25 to 0.5 mg/kg
Single Dose: 0.38 (0.375)
Frequency: 8 hourly
Route: Oral
Instructions: -

Dose: 0.25 to 0.5 mg/kg
Single Dose: 0.38 (0.375)
Frequency: 8 hourly
Route: Oral
Instructions: -

. It is of Synthetic origin and belongs to Isopropylaminoalcohol. It belongs to Beta adrenergic antagonist pharmacological group on the basis of mechanism of action and also classified in Anti arrhythmic agents pharmacological group.The Molecular Weight of Propranolol (HCl) is 295.80. Its pKa is 9.5.

Propranolol (HCl) is contraindicated in conditions like Acidosis,Asthma,Heart failure,Cardiogenic shock,Bronchospasm,Haemorrhage,Heart block.

The severe or irreversible adverse effects of Propranolol (HCl), which give rise to further complications include Thrombocytopenia, Eosinophilia, Agranulocytosis, Visual hallucination, Hypoglycemia.Propranolol (HCl) produces potentially life-threatening effects which include Severe bradycardia, Severe bronchospasm, Hypotension, Bradyarrhythmias, Hypoglycemia, Cardiogenic shock. which are responsible for the discontinuation of Propranolol (HCl) therapy.The signs and symptoms that are produced after the acute overdosage of Propranolol (HCl) include Convulsions, Coma, Seizures.The symptomatic adverse reactions produced by Propranolol (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Fatigue, Nausea, Diarrhea, Cold extremities, Constipation, Insomnia, Impotence, Vivid dreams, Lassitude.

Propranolol (HCl) is primarily indicated in conditions like Angina, Anxiety tachycardia, Arrhythmias, Cardiac arrhythmia, Hypertension, Hypertrophic obstructive cardiomyopathy, Induction and maintenance of anaesthesia, Induction of general anaesthesia, Iron deficiency anaemia, Migraine, Migraine prophylaxis, Obstructive cardiomyopathy, Reduction of raised intracranial pressure, Renal hypertension, Thyrotoxicosis (adjunct), and can also be given in adjunctive therapy as an alternative drug of choice in Anxiety, Phaeochromocytoma, Thyrotoxicosis.

Propranolol (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAdrenalineCoadministration of these drugs leads to hypertension,then bradycardia and stroke may also be reported due to blockade of beta effects of adrenaline.MajorStrict monitoring of patient blood pressure is required if this combination is used or selective beta blockers can be a better alternative.Albuterolco administration of salbutamol with beta blockers such as propanolol, salmeterol , may have a additive effects to contro acute bronchospasm, reduce the sensitivity to salbutamolShould not use concurrently without doctors prescription.AlprostadilEnhanced hypotensive effects when alprostadil given with Beta-blockers (e.g propranolol)Aluminium Hydroxide and OxideBamifyllineBrimonidine (Tartrate)Bupivacaine (HCl)Increased risk of Bupivacaine toxicity when given with Propranolol.Chlormethiazole (Edisylate)Chlorpromazine (HCl)ChlorpropamidePropranolol inhibits the insulin secretion and hepatic glycogenolysis thus potentiate the hypoglycemic effect of chlorpropamide.ModerateClosely monitor the level of blood glucose regularly.CholestyramineCimetidine (HCl)Cimetidine by inhibiting hepatic metabolism increases plasma concentration of propranolol through CYP450 inhibition. ModeratePatient response and tolerance should be monitor.CisplatinClonidine (HCl)Clorazepate (K)Both agents acts additively thus enhances hypotensive and/or CNS depressant effect.ModerateClosely monitor for hypotension and excessive or prolonged CNS depression.Colestipol (HCl)Dexamphetamine (Sulphate)DiazepamDiazoxideEnhanced hypotensive effect when Diazoxide given with Propranolol.DigitoxinDigoxinPropranolol may enhance the bradycardic effect of digoxin.ModerateMonitor for increased bradycardia if these two agents are used concomitantly. Ophthalmic beta-blockers are likely of little concern. Diltiazem (HCl)Both agents act additivelly and reduces the rate,conduction and contractilityof heart results in severe congestive heart failure,hypotension and angina.MajorHemodynamic responses and tolerance should be monitored closely and adjust the dose of one or both agents. Symptoms like fainting, swelling of extremities, weight gain and shortness of breath should be reported promptly.DisopyramideErgotamine (Tartrate)Propranolol increases the risk of arteriospasm associated with ergotamine may lead to peripheral ischemia, hypertension with chest pain and migraine.ModerateIncreases the awareness of interaction.EtherFluvoxamine (Maleate)Fosinopril (Na)GlibenclamideHydralazine (HCl)HydrochlorothiazideIndacaterolBeta-blockers may exacerbate bronchospasms in patients with COPD.monitor closelyIndomethacinIndomethacin alters the antihypertensive effects of propranolol by inhibiting synthesis of renal prostaglandins results in unopposed pressor activity producing hypertension.ModerateClosely monitor the patient for changed antihypertensive response whenever therapy with indomethacin starts, stopped or modified.Interferon AlphaIpriflavoneIsoproterenolPropranolol(HCl) may blunt ionotropic response.IsradipineLacidipineLignocainePropranolol reduces clearance of lignocaine.Magnesium Oxides and HydroxidesMetformin (HCl)propranolol increases the hypoglycemic effect by inhibiting hepatic glycogenolysis and insulin secretion.ModerateClosely monitor the blood glucose level on regular basis.MianserinMinoxidilModafinilConcomitant use may increase the toxicity of modafinil.NaphazolineNaproxenNaproxen may attenuate the anihypertensive effect of propranolol by inhibiting renal prostaglandin synthesis.ModerateClosely monitor for altered antihypertensive response.NicergolineNifedipineCombined use of metoprolol with nifedipine decrease the rate, conduction and contractility of heart particularly in patients of ventricular or conduction abnormalities.by decreasing peripheral vascular resistance.ModerateDosage regimen should be adjusted accordingly. Closely monitor the hemodynamic effect and tolerance of patient.NisoldipineNitroglycerinsimultaneous use of nitroglycerin and ca channel blockers may cause orthostatic hypotension NitroprussideShould not be use concurrently without doctor or pharmacist approval.ParoxetinePhenytoin (Na)PimozideProcainamide (HCl)PropylthiouracilHyperthyroidism may cause an increased clearance of beta blockers with a high extraction ratio. A dose reduction of beta-adrenergic blockers may be needed when a hyperthyroid patient becomes euthyroid.Pyridostigmine (Br) coadministration with beta blockers have the potential to aggravate the symptom of myasthenia gravis and also reports of bradycardia and hypotensionventilationRitodrine (HCl)Propranolol (HCl) may antagonize the effects of ritodrine.TheophyllineThioridazine (HCl)Verapamil (HCl)Warfarin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Determination of Metanephrines by Pisano Method Bilirubin measurements by Diazo Method

Drug should not be given to Pregnant Mothers, Cardiac / Hypertensive Patients, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Inj, Oral Soln Store at room temperature. Do not Freeze. Protect from Sunlight. Tab Store in a well closed container, Below 40°C. Protect from Sunlight and Moisture.

Propranolol should be used with caution in diabetic patients and patients with kidney or liver disease.