Propofol

Propofol is extremely important intravenous anesthetic. Chemically Propofol is 2, 6-di-isopropylphenol. Propofol is chemically unrelated to other intravenous anesthetics. Propofol is used to induce anesthesia that can be maintained by continuous infusion or with inhalation anesthetics. It produces anesthesia at the rate similar to that of intravenous barbiturates, recovery is more rapid, and is associated with minimal postoperative confusion. Unlike many other general anesthetics, it possesses an antiemetic action. It received FDA approval in October 1989.

Brands
POFOL RECOFOL RECOFOL RECOFOL DIPRIVAN FRESOFOL PROPOFOL LIPURO PROPOFOL PROPOFOL PROPOFOL PROPOFOL
Adult Dose
Dose: 200 to 500 mg
Single Dose: 350 (350)
Frequency: As recommended.
Route: IV Inf
Instructions: As Required
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose: 0.125 to 0.3 mg/kg.min
Single Dose: 0.21 (0.2125)
Frequency: As recommended.
Route: IV Infusion
Instructions: Maintenance, As Required
Characteristics
Propofol also known as Disoprofol. . It is of Synthetic origin and belongs to Phenol. It belongs to Chloride Channel opener (Gaba operated) pharmacological group on the basis of mechanism of action and also classified in General Anesthetics pharmacological group.The Molecular Weight of Propofol is 178.00. Its pKa is 11.
Contraindications
Propofol is contraindicated in conditions like Disorders of fat metabolism.
Effects
The severe or irreversible adverse effects of Propofol, which give rise to further complications include CNS depression, Transient bradycardia.Propofol produces potentially life-threatening effects which include Cardiopulmonary depression. which are responsible for the discontinuation of Propofol therapy.The symptomatic adverse reactions produced by Propofol are more or less tolerable and if they become severe, they can be treated symptomatically, these include Thrombophlebitis.
Indications
Propofol is primarily indicated in conditions like Anesthesia, Induction of anaesthesia, Insomnia, Maintenance of anaesthesia, Sedation for surgical and diagnostic proceduers, Sedation in intensive care.
Interactions
Propofol is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementEnfluraneEnflurane can be expected to increase the anesthetic or sedative and cardiorespiratory effects of Propofol Injectable Emulsion.HalothaneHalothane can be expected to increase the anesthetic or sedative and cardiorespiratory effects of Propofol Injectable Emulsion.IsofluraneIsofluraneIsoflurane can be expected to increase the anesthetic or sedative and cardiorespiratory effects of Propofol Injectable Emulsion.MorphineMorphine may increase the anesthetic or sedative effects of Propofol.The induction dose requirements of Propofol Injectable Emulsion may be reduced in patients taking morphine.ParaldehydeConcurrent use is not recommended, but may be required in some cases.If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.Vecuronium (Br) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store Below 20°C. Refrigeration and Freezing is not recommended. Protect from Sunlight.
Warnings
Propofol should be given with caution in patients with hypovolumia, epilepsy, lipid metabolism disorder, and in elderly. It should not be used with electroconvulsive therapy. Propofol is not recommended as an anaesthetic in children under 3 years of age.
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