Propantheline (Br)

Propantheline (Br) is antimuscarinic with action, uses and adverse effects similar to those of atropine. Propantheline (Br) is used as an antispasmodic for gastro-intestinal and urinary complaints. Propantheline (Br) is also reduces the secretion of gastric acid and used in peptic ulcer disease.

Brands
PROBANTHINE
Adult Dose
Dose: 15 mg
Single Dose: 15 (15)
Frequency: 8 hourly
Route: PO
Instructions: 1 hour before meal.
Neonatal
Paedriatic
Dose: 0.375 mg/kg
Single Dose: 0.38 (0.375)
Frequency: 6 hourly
Route: oral
Instructions:
Characteristics
. It is of Synthetic origin and belongs to Quaternary Ammonium. It belongs to Cholinergic muscarinic antagonist pharmacological group on the basis of mechanism of action and also classified in Gastrointestinal Anticholinergics/Antispasmodics pharmacological group.The Molecular Weight of Propantheline (Br) is 448.50.
Contraindications
Propantheline (Br) is contraindicated in conditions like Cardiac arrhythmia,Glucoma,Reflux oesophagitis,Prostatic hypertrophy.
Effects
The severe or irreversible adverse effects of Propantheline (Br), which give rise to further complications include Tachycardia, Glaucoma, Orthostatic hypotension, Urinary retention.Propantheline (Br) produces potentially life-threatening effects which include GI reactions, Cardiac arrhythmias. which are responsible for the discontinuation of Propantheline (Br) therapy.The signs and symptoms that are produced after the acute overdosage of Propantheline (Br) include Respiratory arrest, Neuromuscular blockade.The symptomatic adverse reactions produced by Propantheline (Br) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Impotence.
Indications
Propantheline (Br) is primarily indicated in conditions like Adjunctive treatment of partial seizures, Diverticulitis, Duodenal ulcer, GI motality disorder, Hyperhidrosis, Menieres disease, Peptic ulcer, Symptomatic relief of GI-disorders, Urgency and incontinence, and can also be given in adjunctive therapy as an alternative drug of choice in Enuresis, Pancreatitis, Short bowel syndrome.
Interactions
Propantheline (Br) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCefpodoximeChlorothiazideDigoxinDisopyramideFosinopril (Na)NitrofurantoinParacetamolPropantheline decreases the gastrointestinal absorption of acetaminophen by reducing gastric motility and delaying gastric emptying.Minor These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Closely monitor patients for therapeutic response and side effects of propantheline. It should not used in high dose because may produce mental depression and mental distrubances. It should be used with caution in patients over 40yr because may increase the risk of glaucoma. It should be used with caution in patients with asthma, heart or renal (kidney) diseases. It should be used with caution in infants and small children.
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