PROGEN SYRUP PROGEN SYRUP PROGEN SYRUP

Dose: 50 to 100 mg
Single Dose: 75 (75)
Frequency: 8 hourly
Route: IM
Instructions: Frequency may be increased upto 4 times/day if needed.

. It is of Synthetic origin and belongs to Phenothiazine. It belongs to D2 antagonist pharmacological group on the basis of mechanism of action and also classified in Psychotherapeutic Drugs and Hypnotic, Sedative pharmacological group.The Molecular Weight of Promazine (HCl) is 320.90. Its pKa is 9.4.

Promazine (HCl) is contraindicated in conditions like Coma,Narrow-angle glaucoma.

The severe or irreversible adverse effects of Promazine (HCl), which give rise to further complications include Parkinsonism, Thrombophlebitis, Extrapyramidal symptoms, Gangrene, Obstructive jaundice, Abnormal liver function, Arteriolar spasm.Promazine (HCl) produces potentially life-threatening effects which include Agranulocytosis, Leucopenia. which are responsible for the discontinuation of Promazine (HCl) therapy.The signs and symptoms that are produced after the acute overdosage of Promazine (HCl) include Coma, Seizures, Hallucinations, Ataxia, Respiratory depression, Grand Mal Seizures (epilepsy), Restlessness, Excitation, Sedation, Rapid fall in BP, CNS excitation, Anxiety, Sleepiness, Deep sleep, Akathisia.The symptomatic adverse reactions produced by Promazine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Drowsiness, Tachycardia, Constipation, Dry mouth, Blurred vision, Confusion, Hypotension, Postural hypotension, Nasal congestion, Urinary hesitancy, Epilepsy, Breast enlargement.

Promazine (HCl) is primarily indicated in conditions like Adjunct to analgesia, Agitation, Alcohol withdrawal, Insomnia, Intractable hiccup, Muscle spasm of varied aeitology, Psychomotor agitation.

Promazine (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholBuspirone (HCl)Cimetidine (HCl)CocainedeferoxamineDisulfiramKaolinProgesteroneStilboestrolSuxamethonium (Cl) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Estimation of alkaloids,barbiturates,17-ketosteroids,17-hydroxycorticosteroids in urine. Estimation of 5-hydroxyindoleacetic acid,protein & salicylates in urine.

Drug should not be given to Paediatrics, Cardiac / Hypertensive Patients, Geriatrics, patients suffering from Liver Malfunction, Neonates, and Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Tab, Susp, Soln, IV Inj, IM Inj Store Below 25°C. Do not Freeze. Protect from Sunlight.

Promazine should be used with caution in patients exposed to extreme heat or phosphorus insecticides, patients in state of alcohol withdrawal, patients with history of peptic ulcer, allergic reactions, with renal (kidney) impairment, prostatic hypertropy. Photosensitization may occur, caution patients against exposure to sunlight or UV light. Discontinue use atleast 48 hr before myelography.