MENSTROGEN GRAVIBINAN GRAVIBINAN PROGESTERONE PROLUTON DEPOT GLOBINAN GLOBINAN GASTRONE DEPOT CYCLOGEST CYCLOGEST UTROGESTAN U-PROGEST

Dose: 25 to 100 mg
Single Dose: 62 (62.5)
Frequency: 24 hourly
Route: IM
Instructions:

Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group

Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group

Progesterone also known as Pregnenedione, Pregnenedione. . It is of Natural origin and belongs to Steroid. It belongs to Progesterone agonist pharmacological group on the basis of mechanism of action and also classified in Sex Hormones pharmacological group.The Molecular Weight of Progesterone is 314.50. Its pKa is not relevant.

Progesterone is contraindicated in conditions like Vaginal bleeding,Cancer,Liver diseases.

The severe or irreversible adverse effects of Progesterone, which give rise to further complications include Amenorrhea, Menstrual irregularities.The signs and symptoms that are produced after the acute overdosage of Progesterone include Fainting, Euphoria, Uterine cramps.The symptomatic adverse reactions produced by Progesterone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Diarrhea, Weight gain, Acne, Weight loss, Anal soreness.

Progesterone is primarily indicated in conditions like Abortion, Dysfunctional uterine bleeding, Postnatal depression, Premenstrual syndrome, Premenstural syndrome.

Progesterone is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAminoglutethimideAminoglutethimide reduces the plasma concentration of Progesterone.AmobarbitalAmobarbital accelerates the metabolism of estrogen; reduced contraceptive effect.MajorBosentanBosentan possibly causes contraceptive failure of hormonal contraceptives containing Progesterone (alternative contraception recommended).MajorCarbamazepineCarbamazepine accelerates metabolism of Progesterone (reduced contraceptive effect).MajorWomen recieving carbamazepine should be given a contraceptive pill containing 50 mcg of estrogen together with a high dose of progesterone.Danazoldanazol acts by binding to estrogen , progesterone or androgen receptor at various levels in the hypothalamic pituitary ovarian axis. danazol may compete for binding sites.MetyraponeNelfinavirNevirapinePhenobarbitonePhenytoin (Na)Promazine (HCl)RepaglinideProgesterone may increase repaglinide concentrations. RifampicinRitonavirThymomodulinThymomodulin may antagonize progetserones in their effectiveness on the lymphatic system and bone marrow. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Pregnanediol Test Metyrapone Test

Drug should not be given to Paediatrics, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Inj Store Below 40°C. Protect from Sunlight and Heat.

Progesteron should be used with caution in patients with any allergy (especially drug allergies), abnormal vaginal bleeding, liver, kidney or heart disease, cancer of the breast or genitals, missed abortion, blood clots, seizures, migraine, asthma, depression or diabetes. Limit alcohol, as this may increase side effects of this drug. It should be used with caution while performing tasks requiring mental alertness (e.g.driving) as this drug may cause drowsiness.