Procyclidine (HCl)

'Procyclidine (HCl) is antimuscarinic agent. Chemically Procyclidine (HCl) is identified as a-cyclohexyl-a-phenyl-1-pyrrolidinepropanol hydrochloride. Procyclidine (HCl) is used mostly as a substitute for trihexyphenidyl in the treatment of parkinson''s disease.'


Adult Dose
Dose: 2.5 mg
Single Dose: 2.5 (2.5)
Frequency: 8 hourly
Route: PO
Instructions: Gradually increased to 5mg.
Neonatal
Dose: 0.312 mg/kg
Single Dose: 0.31 (0.312)
Frequency: As recommended.
Route: Intramuscular
Instructions: Single dose
Paedriatic
Dose: 0.071 to 0.142 mg/kg
Single Dose: 0.11 (0.1065)
Frequency: As recommended.
Route: Intra Muscular
Instructions: Maintenance for once or repeat/20 min As Required
Characteristics
. It is of Synthetic origin and belongs to Alkaloid. It belongs to Cholinergic muscarinic antagonist pharmacological group on the basis of mechanism of action and also classified in Antiparkinson Agents pharmacological group.The Molecular Weight of Procyclidine (HCl) is 323.90. Its pKa is 10.7.
Contraindications
Procyclidine (HCl) is contraindicated in conditions like Prostatic hypertrophy,Tardive dyskinesias,Intestinal obstruction,Narrow-angle glaucoma.
Effects
The severe or irreversible adverse effects of Procyclidine (HCl), which give rise to further complications include Dizziness, Visual hallucination, Excitement.Procyclidine (HCl) produces potentially life-threatening effects which include Confusion. which are responsible for the discontinuation of Procyclidine (HCl) therapy.The signs and symptoms that are produced after the acute overdosage of Procyclidine (HCl) include Blurred vision, Constipation, Dry mouth, Urinary retention, Confusion, Agitation, Restlessness, Visual hallucination.The symptomatic adverse reactions produced by Procyclidine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Restlessness, Constipation, Dry mouth, Blurred vision, Urinary retensionX, Confusion, Agitation.
Indications
Procyclidine (HCl) is primarily indicated in conditions like Acromegaly, Acute dystonia, Dystonia, Oculogyric crises, Parkinsonism.
Interactions
Procyclidine (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAmantadine (HCl)ErythromycinParoxetineQuinidine These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
None well documented
Risks
Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Procyclidine should be used with caution in patients with heart, liver, kidney or obstructive gastrointestinal (GI) diseases. Patient should observe caution while driving or performing other tasks requiring alertness because may impair mental or physical abilities. It should be used with caution in hot weather. Reduce dose or discontinue therapy if loss of appetite or weight occur.
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