Procaine Penicillin

Procaine Penicillin is a long acting penicillin similar to benzylpenicillin, used to treat a large variety of bacterial infections. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular intervals of time throughout the day and night as prescribed. Procaine Penicillin is important to take the drug for the full time period as prescribed. If you discontinue the therapy may result in ineffective treatment.

Brands
POLYBIOTIC POLYBIOTIC KANACILLIN PLAIN PROCAINE PENICILLIN KANACILLIN FORTE PROCAINE PENECILLIN FORTE
Adult Dose
Dose: 4 MIU
Single Dose: 4 (4)
Frequency: As recommended.
Route: IM
Instructions:
Neonatal
Paedriatic
Dose: 10 mg/kg
Single Dose: 10 (10)
Frequency: 24 hourly
Route: Intra Muscular
Instructions: -
Characteristics
Procaine Penicillin also known as Benzyl Penicillin Novocain, Benzyl Penicillin Novocain. . It is of Natural origin and belongs to Aminobenzoate. It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.The Molecular Weight of Procaine Penicillin is 588.70.
Contraindications
Procaine Penicillin is contraindicated in conditions like Hypersensitivity to any component of product.
Effects
The severe or irreversible adverse effects of Procaine Penicillin, which give rise to further complications include Hemolytic anemia, Serum sickness, Jarisch herxheimer reaction, Renal impairment.Procaine Penicillin produces potentially life-threatening effects which include Convulsions, Hypotension, Hematological abnormalities, Renal damage, Cardiopulmonary arrest, Anaphylaxis. which are responsible for the discontinuation of Procaine Penicillin therapy.The symptomatic adverse reactions produced by Procaine Penicillin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Anxiety, Tachycardia, Skin rashes, Pain, Contact dermatitis, Hypertension, Abscess.
Indications
Procaine Penicillin is primarily indicated in conditions like Bacterial infections, Gonorrhoea, Syphilis, and can also be given in adjunctive therapy as an alternative drug of choice in Endocarditis, Pneumonia.
Interactions
Procaine Penicillin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAmpicillinChloramphenicolDistigmine (Br) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Flase +ve values of 17-OH-Corticosteroids, 17-Ketosteroids, 17-Ketogenic Steroids It may interferes with Thyroid Function Test
Risks
Drug should not be given to patients suffering from Kidney dysfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store Below 40°C.
Warnings
Procain penicillin should be used with caution in patients with any kidney disease, stomach or intestine diseases or allergies to penicillins, other antibiotics, procainamide, ester-type anesthetics (e.g.lidocaine) or PABA products (e.g.methylparaben). It should be used with caution during pregnancy or lactation.
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