Probucol

Probucol is an antihyperlipidimic agent, used in the treatment of primary hypercholesterolemia. Chemically Probucol is identified as acetone bis (3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole, a substituted bis-phenol structurally unrelated to other currently available antihyperlipidemic agents. It exerts its lipid-lowering action mainly on cholesterol, with relatively little effect on triglycerides. It inhibits the transport of cholesterol from the intestine and may interfere with the conversion of acetate to mevalonic acid, an early stage in cholesterol synthesis, but does not affect the later stages of cholesterol synthesis. It may also increase the fecal excretion of cholesterol and bile acids via the bile. it was approved by the FDA in 1977.

Brands
Adult Dose
Dose: 7.14 mg/kg
Single Dose: 7.1 (7.14)
Frequency: 12 hourly
Route: PO
Instructions: -
Neonatal
Paedriatic
Dose: Safety not established
Single Dose:
Frequency:
Route:
Instructions:
Characteristics
. It is of Synthetic origin and belongs to Phenols. It belongs to Lipid lowering agents pharmacological group on the basis of mechanism of action and also classified in Antilipemic Agent pharmacological group.The Molecular Weight of Probucol is 516.90.
Contraindications
Probucol is contraindicated in conditions like Cardiac arrhythmia,Diarrhoea.
Effects
Probucol produces potentially life-threatening effects which include Torsades de pointes. which are responsible for the discontinuation of Probucol therapy.The symptomatic adverse reactions produced by Probucol are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea.
Indications
Probucol is primarily indicated in conditions like Hypercholesterolaemia.
Interactions
Probucol is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementArtemisininColestipol (HCl)Colestipol (HCl)LycopeneCholesterol-lowering drugs and fat substitutes,may decrease the absorption of lycopene may decrease the absorption of lycopeneVORICONAZOLEAdditive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Elevations of SGPT and SGOT Increased Alkaline Phosphatase LevelsElevation in ALT or ASTIncreased level of Blood urea nitrogen (BUN) concentrationsIncreased blood glucose levelIncreases serum uric acidIncreased concentration of creatinine kinase
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store in a well closed container, at room temperature. Protect from Sunlight and Moisture.
Warnings
Determine serum lipid level before treatment. If satisfactory lipid alteration is not achieved discontinue therapy.
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