Dose: 1.43 to 1.79 mg/kg
Single Dose: 1.6 (1.61)
Frequency: As recommended.
Route: PO
Instructions: Initially for 9 Days

Dose: 5 mg/kg
Single Dose: 5 (5)
Frequency: 24 hourly
Route: Oral
Instructions: Initially at Bed time

Dose: 5 mg/kg
Single Dose: 5 (5)
Frequency: 24 hourly
Route: Oral
Instructions: Initially at Bed time

Primidone also known as Hexamidinum, Hexamidinum. . It is of Synthetic origin and belongs to Pyrimidine. It belongs to Anticonjuctivitis pharmacological group on the basis of mechanism of action and also classified in Antipsychotic Agent pharmacological group.The Molecular Weight of Primidone is 218.30. Its pKa is not relevant.

Primidone is contraindicated in conditions like Porphyrias.

The severe or irreversible adverse effects of Primidone, which give rise to further complications include Vertigo, Ataxia, Nausea, Vomiting, Drowsiness.Primidone produces potentially life-threatening effects which include Lupus erythematosus, Hepatitis, Dermatitis bullosa striata pratensis. which are responsible for the discontinuation of Primidone therapy.The signs and symptoms that are produced after the acute overdosage of Primidone include Crystalluria, CNS depression, Depression of deep tendon reflexes, Flaccidity.The symptomatic adverse reactions produced by Primidone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Sleepiness, Irritability, Ataxia, Tremors, Impotence, Loss of libido, Loss of memory, Nystagmus.

Primidone is primarily indicated in conditions like Epilepsy, Essential tumor.

Primidone is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAcetazolamide (Na)AlcoholCarbamazepinePrimidone, ethosuximide, methsuximide, ethylphenacemide will decrease carbamazepine plasma concentration.CarbamazepineChloramphenicolCortisone (Acetate)DeflazacortDesogestrelDesonideDoxicycline HyclateEstradiol (Valerate)Ethynodiol (Diacetate)Fludrocortisone (Acetate)FluprednisoloneFluticasone PropionateGestodeneHydrocortisoneIsoniazidLamotrigineLevonorgestrelLynoestrenolMethylphenidate (HCl)NicotinamideNicotinamideNorgestimateParoxetinePhenytoin (Na)Phenytoin (Na)Prednisolone and PrednisonePropoxypheneSodium ValproateVORICONAZOLEThe barbiturate, primidone, decreases the effect of voriconazole. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Measurement of Urinary Pregnanediol by Gas Chromatographic Method

Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Susp Store Below 40°C. Do not Freeze. Protect from Sunlight and Moisture. Tab Store Below 40°C. Protect from Sunlight and Moisture.

Perform complete blood counts test after every 6 months because therapy generally extends over prolonged period.