Primaquine (Phosphate)

Primaquine (Phosphate) is antimalarial agent. Primaquine (Phosphate) is a synthetic 8-aminoquinoline derivative. Primaquine (Phosphate) is effective against the late hepatic stages of Plasmodium vivax and Plasmodium ovale and the primary exoerythrocytic stages of Plasmodium falciparum.

Brands
PRIMAQUINE
Adult Dose
Dose: 15 mg
Single Dose: 15 (15)
Frequency: 24 hourly
Route: PO
Instructions: For 14 Days
Neonatal
Dose: 0.25 mg/kg
Single Dose: 0.25 (0.25)
Frequency: 24 hourly
Route: Oral
Instructions: For 2-3 Weeks
Paedriatic
Dose: 0.25 mg/kg
Single Dose: 0.25 (0.25)
Frequency: 24 hourly
Route: Oral
Instructions: For 2-3 Weeks
Characteristics
. It is of Synthetic origin and belongs to Quinolone. It belongs to Antiplasmodial pharmacological group on the basis of mechanism of action and also classified in Antimalarial Agent pharmacological group.The Molecular Weight of Primaquine (Phosphate) is 455.30.
Contraindications
Primaquine (Phosphate) is contraindicated in conditions like G6pd deficiency,Granulocytopenia.
Effects
The severe or irreversible adverse effects of Primaquine (Phosphate), which give rise to further complications include Cardiac arrhythmias, Hypertension, Depression, Cyanosis.Primaquine (Phosphate) produces potentially life-threatening effects which include Hemolytic anemia. which are responsible for the discontinuation of Primaquine (Phosphate) therapy.The signs and symptoms that are produced after the acute overdosage of Primaquine (Phosphate) include Nausea, Vomiting, Jaundice, Hemolysis, Anorexia, Methemoglobinemia, Cyanosis, Weakness, Bone marrow suppression.The symptomatic adverse reactions produced by Primaquine (Phosphate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Confusion, Epigastric discomfort.
Indications
Primaquine (Phosphate) is primarily indicated in conditions like Diagnosis of dual block due to suxamethonium, Iron deficiency anaemia, Malaria, Malaria prophylaxis, NSAID-associated gastric or duodenal ulcers (prophylaxis).
Interactions
Primaquine (Phosphate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementChloroquineMepacrine (HCl)SulfapyridineConcurrent use with sulfapyridine may increase the potential for toxic side effects These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
TLC Tests for Barbiturates and Alkaloids in Urine
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store in a well closed container, Below 40°C. Protect from Sunlight.
Warnings
Primaquine should be used with caution in patients with any pre-existing blood disorders, arthritis, psoriasis, lupus erythematous, glucose-6-phosphate dehydrogenase (G-6-PD) deficiency, liver disease or any allergy. It should be used only if clearly needed during pregnancy.
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