Dose: 2.86 to 5.71 mg/kg
Single Dose: 4.3 (4.285)
Frequency: As recommended.
Route: IV
Instructions: As Required

Prilocaine also known as Prilocanium. Prilocaine (HCl) is the derivative of Prilocaine. It is of Synthetic origin and belongs to Amide. It belongs to Na-Channel Local Anesthetic antagonist pharmacological group on the basis of mechanism of action and also classified in Local Anesthetics pharmacological group.The Molecular Weight of Prilocaine is 220.30. It is weakly acidic drug, 4.18% solution of the drug is isotonic and Its pKa is 7.9.

Prilocaine is contraindicated in conditions like Anaemia,Methaemoglobinaemia.

The severe or irreversible adverse effects of Prilocaine, which give rise to further complications include Skin rashes, Methemoglobinemia, Tremors, Porphyria, Hypersensitivity.Prilocaine produces potentially life-threatening effects which include Tinnitus, Anxiety, Circumoral numbness, Cardiovascular depression, Cardiac Arrest. which are responsible for the discontinuation of Prilocaine therapy.The signs and symptoms that are produced after the acute overdosage of Prilocaine include Seizures, CNS toxicity, Methemoglobinemia, Anxiety, Cyanosis, Numbness.The symptomatic adverse reactions produced by Prilocaine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Vertigo, Nausea, Hypersensitivity reactions, Nystagmus.

Prilocaine is primarily indicated in conditions like Infiltration anaesthesia (higher strengths for dental use only), Local anaesthesia, Local anaesthetic, Surgical anaesthesia, and can also be given in adjunctive therapy as an alternative drug of choice in Pain in short surgical procedure..

No data regarding the interactions of Prilocaine was found.

Measurement of Plasma Cholinesterases

Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Inj Store Below 25°C.

Avoid Prilocain in patient with known hypersensitivity. It should be given with caution to the elderly, to debilitated, to children, patients with epilepsy, impaired cardiac conduction or respiratory function, shock or liver damage. It might be ototoxic and should not be instilled into the middle ear. The application of local anesthetics to the skin for prolonged period or to the extensive area should be avoided. It should be avoided in patients with anemia, congenital or acquired methaemoglobinaemia, cardiac or ventilatory failure or hypoxia. Be careful and avoid injury until anesthetic wears off.