Practolol

Practolol is a cardio-selective beta receptor blocking drug. Nowadays Practolol is not used because of its toxic effect on eyes and ear.

Brands
Adult Dose
Dose: 0.07 to 0.29 mg/kg
Single Dose: 0.18 (0.18)
Frequency: As recommended.
Route: IV
Instructions: As Required
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Synthetic origin and belongs to Acetanilide. It belongs to Beta-1 adrenergic antagonist pharmacological group on the basis of mechanism of action and also classified in Antihypertensive Agents pharmacological group.The Molecular Weight of Practolol is 266.30. Its pKa is 9.5.
Contraindications
Practolol is contraindicated in conditions like Acidosis,Cardiogenic shock,Heart block,Bradycardia,Refractory heart failure.
Effects
The severe or irreversible adverse effects of Practolol, which give rise to further complications include Heart failure, SLE-like syndrome, Practolol induced syndrome.The signs and symptoms that are produced after the acute overdosage of Practolol include Bradycardia.The symptomatic adverse reactions produced by Practolol are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Nausea, Constipation, Bradycardia, Hypotension, Bronchospasm, Paresthesias.
Indications
Practolol is primarily indicated in conditions like Angina, Cardiac arrhythmia.
Interactions
Practolol is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementClonidine (HCl)DisopyramideDisopyramideEtherHalothaneVerapamil (HCl) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
The drug should not be used in sinus bradycardia, when heart block is more than 1st degree, cardiogenic shock and cardiac failure.
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