Porcine Insulin

Porcine Insulin is a type of soluble Insulin extracted from the pancreas of porcus a pig or hog, contains 51 amino acid arranged in two chains (A and B) joined together by disulfide linkage. It differs from human insulin in only one amino acid in the beta chain. Porcine Insulin is a short-acting form of insulin, used in the management of diabetes mellitus, and diabetic ketoacidosis.

Brands
Adult Dose
Dose: 0.05 to 0.2 IU/kg
Single Dose: 0.12 (0.125)
Frequency: 12 hourly
Route: IV
Instructions: Dose depends upon Blood Sugar Level
Neonatal
Paedriatic
Characteristics
. It is of Natural origin and belongs to Polypeptide. It belongs to Insulin agonist pharmacological group on the basis of mechanism of action and also classified in Antidiabetic Agent, Insulin pharmacological group.The Molecular Weight of Porcine Insulin is 5777.60.
Contraindications
Porcine Insulin is contraindicated in conditions like Hypersensitivity to the drug.
Effects
Porcine Insulin produces potentially life-threatening effects which include Hypoglycemia, Hypoglycemia. which are responsible for the discontinuation of Porcine Insulin therapy.The symptomatic adverse reactions produced by Porcine Insulin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Lipohypertrophy.
Indications
Porcine Insulin is primarily indicated in conditions like Diabetes mellitus, Hyperkalaemia.
Interactions
Porcine Insulin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAdrenalineAlcoholAspirinCaptoprilACE inhibitors (e.g Captopril) possibly enhance hypoglycemic effect of insulin. Chlorpromazine (HCl)Clonidine (HCl)CyclophosphamideDiltiazem (HCl)GuanethidineIsoniazidMetformin (HCl) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Monitoring of blood and urine glucose
Risks
Drug should not be given to Pregnant Mothers, and Cardiac / Hypertensive Patients.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store at room temperature or refrigerator. Do not Freeze. Protect from Sunlight. Use within 2 yrs (at 4C) if refrigerated and within 1 month if kept at room temperature.
Warnings
Patients should be instructed regarding their dosage and should be reminded that this formulation requires the administration of a smaller volume of solution than is the case with less concentrated formulations.
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