Polythiazide

Polythiazide is a thiazide diuretic used orally in the treatment of oedema and hypertension.


Brands
Adult Dose
Dose: 0.007 to 0.057 mg/kg
Single Dose: 0.032 (0.032)
Frequency: 24 hourly
Route: PO
Instructions: -
Neonatal
Dose: Not used in this age group
Single Dose:
Frequency:
Route:
Instructions:
Paedriatic
Dose: Not used in children
Single Dose:
Frequency:
Route:
Instructions:
Characteristics
. It is of Synthetic origin and belongs to Benzothiadiazine. It belongs to NaCl cotransport inhibitor pharmacological group on the basis of mechanism of action and also classified in Diuretic Thiazide pharmacological group.The Molecular Weight of Polythiazide is 440.00. Its pKa is 9.1.
Contraindications
Polythiazide is contraindicated in conditions like Diabetes mellitus,Hypokalaemia.
Effects
The severe or irreversible adverse effects of Polythiazide, which give rise to further complications include Atherosclerosis.Polythiazide produces potentially life-threatening effects which include Hyponatremia, Hypokalemia. which are responsible for the discontinuation of Polythiazide therapy.The signs and symptoms that are produced after the acute overdosage of Polythiazide include Hypotension, Volume depletion, Hypokalemia, Renal failure, Hyponatremia.The symptomatic adverse reactions produced by Polythiazide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Gout, Impotence.
Indications
Polythiazide is primarily indicated in conditions like Diabetes insipidus, Edema, Heart failure, Hypercalciuria, Hypertension, Oedema.
Interactions
No data regarding the interactions of Polythiazide was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab, Caps Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Thiazide diuretics increase sensitivity to sunlight, avoid prolonged sun exposure, use a sunscreen and wear protective clothing. It should be used during pregnancy or lactation only if clearly needed. It should be used with caution in patients with medical history especially if have gout or diabetes, or any allergy especially to sulfa medications. Avoid any drug that increase heart rate or cause excitation like decongestants (found in cough and cold products) because it may counter-act blood pressure medicine.
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