Pivmecillinam (HCl)

Pivmecillinam (HCl) is antibiotic and is used to treat a large variety of bacterial infections, such as respiratory tract infections, middle ear infections, skin infections and urinary tract infections. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular intervals of time throughout the day and night as prescribed. Pivmecillinam (HCl) is important to take the drug for the full time period as prescribed. Discontinuation of the drug may result in ineffective treatment.

Brands
Adult Dose
Dose: 2.857 mg/kg
Single Dose: 2.9 (2.857)
Frequency: 8 hourly
Route: PO
Instructions: Maintenance, upto 8 doses
Neonatal
Dose: 5 to 10 mg/kg
Single Dose: 7.5 (7.5)
Frequency: 6 hourly
Route: Oral
Instructions:
Paedriatic
Dose: 5 to 10 mg/kg
Single Dose: 7.5 (7.5)
Frequency: 6 hourly
Route: Oral
Instructions: -
Characteristics
. It is of Semi Synthetic origin and belongs to Beta Lactum. It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.The Molecular Weight of Pivmecillinam (HCl) is 476.00. Its pKa is 8.9.
Contraindications
Pivmecillinam (HCl)
Effects
The symptomatic adverse reactions produced by Pivmecillinam (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea, Anaphylactoid reactions, Abdominal pain, Mouth ulcers, Nausea and vomiting, Thrombocytopenia, Eosinophilia, Granulocytopenia, Oesophageal ulcerations, Oesophagitis.
Indications
Pivmecillinam (HCl) is primarily indicated in conditions like Acute uncomplicated cystitis, Chronic or recurrent bacteriuria, Salmonellosis, UTI.
Interactions
No data regarding the interactions of Pivmecillinam (HCl) was found.
Interfrence
Liver Function Test (LFT)
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab, Oral Susp Store in refrigerator. Protect from Sunlight.
Warnings
During long term use, it is advisable to carry out routine liver and kidney function tests. Pivmecillinam (HCl) should be used with caution in patients with porphyria since pivmecillinam has been associated with acute attacks of porphyria. As with other antibiotics which are excreted mainly by the kidneys, raised blood levels of mecillinam may occur if repeated doses are given to patients with impaired renal function. Pivmecillinam (HCl) should be used with caution for long-term or frequently-repeated treatment, due to the possibility of carnitine depletion.
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