Pirenzepine (di HCl)

Pirenzepine (di HCl) is a selective M1 antimuscarinic agent, which has a preferential action on the gastric mucosa, causing reduced gastric acid secretion. Pirenzepine (di HCl) is used in the management of peptic ulcer disease.


Brands
Adult Dose
Dose: 0.238 to 0.714 mg/kg
Single Dose: 0.48 (0.476)
Frequency: 8 hourly
Route: PO
Instructions: -
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Natural origin and belongs to Benzodiazepine. It belongs to Cholinergic muscarinic antagonist pharmacological group on the basis of mechanism of action and also classified in Gastrointestinal Anticholinergics/Antispasmodics and Antipeptic Ulcerant pharmacological group.The Molecular Weight of Pirenzepine (di HCl) is 424.30. Its pKa is 2.1, 8.1.
Contraindications
Pirenzepine (di HCl) is contraindicated in conditions like Renal failure.
Effects
The signs and symptoms that are produced after the acute overdosage of Pirenzepine (di HCl) include Anticholinergic effects.The symptomatic adverse reactions produced by Pirenzepine (di HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dry mouth, Disturbances of accomodation.
Indications
Pirenzepine (di HCl) is primarily indicated in conditions like Benign gastric ulcer, Duodenal ulcer.
Interactions
No data regarding the interactions of Pirenzepine (di HCl) was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Protect from Moisture.
Warnings
Pirenzepine should be used with caution in patients with renal (kidney) impairment, particularly those with end-stage renal failure. Avoid use in patients with angle closure glaucoma.
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