Argipressin

Argipressin is a form of vasopressin. Vasopressin is the pressor and antidiuretic principle of posterior lobe of pituitary gland. It may be prepared by synthesis or by extraction from the glands of healthy, domestic animals used for food in man. Vasopressin plays an important role in the long term control of blood pressure through its action on the kidney to increase water reabsorption.

Brands
Adult Dose
Dose: 0.003 to 0.01 IU/kg.min
Single Dose: 0.0065 (0.0065)
Frequency: As recommended.
Route: IV Inf
Instructions: For 24-Hours
Neonatal
Dose: 0.25 to 0.5 IU/kg
Single Dose: 0.38 (0.375)
Frequency: 8 hourly
Route: Intra Muscular
Instructions: Dose for diabetes insipidus
Paedriatic
Dose: 0.25 to 0.5 IU/kg
Single Dose: 0.38 (0.375)
Frequency: 8 hourly
Route: Intra Muscular
Instructions: Dose for diabetes insipidus
Characteristics
. It is of Synthetic origin and belongs to Polypeptide. It belongs to Vasopressin V1+V2 agonist pharmacological group on the basis of mechanism of action and also classified in Posterior Pituitary Hormones pharmacological group.The Molecular Weight of Argipressin is 1084.00. Its pKa is 10.9.
Contraindications
Argipressin is contraindicated in conditions like Hypertension,Renal diseases,Cardiovascular disease,Primary polydipsia.
Effects
Argipressin produces potentially life-threatening effects which include Myocardial infarction, Myocardial Ischemia, Cardiac dysrhythmias. which are responsible for the discontinuation of Argipressin therapy.The signs and symptoms that are produced after the acute overdosage of Argipressin include Angina.
Indications
Argipressin is primarily indicated in conditions like Bleeding oesophageal varices, Diabetes insipidus.
Interactions
No data regarding the interactions of Argipressin was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
IM Inj, SC Inj, IV Inf Store in refrigerator. Do not Freeze.
Warnings
Avoid use argipressin in patients with chronic nephritis with nitrogen retension. Use with caution and in small doses in patients with vascular disease, especially of coronary arteries. It should be given with care to patients with asthma, migrane, epilepsy, heart failure or hypertension. Fluid retention should be adjusted to avoid hyponatraemia.
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