Piperazine

Piperazine is anthelmintic agent. Piperazine is available as hexahydrate and as a variety of salts such as citrate, phosphate, adipate, tartrate etc. Piperazine is used in the treatment of threadworms and round worms.


Adult Dose
Dose: 3 to 5 g
Single Dose: 4 (4)
Frequency: 24 hourly
Route: PO
Instructions: For 2 days.
Neonatal
Dose: 100 mg/kg
Single Dose: 100 (100)
Frequency: 24 hourly
Route: Oral
Instructions: Recommended for Ascariasis
Paedriatic
Dose: 100 mg/kg
Single Dose: 100 (100)
Frequency: 24 hourly
Route: Oral
Instructions: Recommended for Ascariasis
Characteristics
. It is of Natural origin and belongs to Piperidine. It belongs to Anthelmintics pharmacological group.The Molecular Weight of Piperazine is 86.14. Its pKa is 4.2.
Contraindications
Piperazine is contraindicated in conditions like Epilepsy,Impaired hepatic function,Impaired renal function.
Effects
Piperazine produces potentially life-threatening effects which include Ataxia, Clonic convulsions, Muscle hypotonia, Somnolence, Impaired conciousness. which are responsible for the discontinuation of Piperazine therapy.The signs and symptoms that are produced after the acute overdosage of Piperazine include Convulsions, Coma.The symptomatic adverse reactions produced by Piperazine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Urticaria, Allergic reactions, GI upset, Purpura, Acute hepatitis, Acute hemolysis.
Indications
Piperazine is primarily indicated in conditions like Helminth infection.
Interactions
Piperazine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementBephenium HydroxynaphthoateChlorpromazine (HCl)Methotrimeprazine (Maleate)Pyrantel PamoatePyrantel PamoateSulpiride These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Estimation of Serum Uric Acid
Risks
Drug should not be given to Paediatrics, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
syrup Store in a well closed container, Below 40°C.
Warnings
The drug should be used with extreme caution in renal or hepatic impairment and in seizures.
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