Piperacillin (Na)

Piperacillin (Na) is a parenteral, semisynthetic, extended-spectrum acylureidopenicillin. Extended-spectrum penicillins, such as piperacillin, are used mainly in the treatment of serious, gram-negative infections and in combination with an aminoglycoside to treat systemic Pseudomonas infections. Clinically, piperacillin is used to treat intra-abdominal infections, respiratory and urinary tract infections, skin and soft-tissue infections, and other infections caused by susceptible organisms. Piperacillin was approved by the FDA in 1981. its patent expired in September 1995. Piperacillin is a β-lactam antibiotic and is mainly bactericidal. It inhibits the third and final stage of bacterial cell wall synthesis by preferentially binding to specific penicillin-binding proteins (PBPs) that are located inside the bacterial cell wall. Penicillin-binding proteins are responsible for several steps in the synthesis of the cell wall and are found in quantities of several hundred to several thousand molecules per bacterial cell. Penicillin-binding proteins vary among different bacterial species.

Brands
TAZOCIN TANZO TANZO TAZOBACT TAZOBACT COMBICIN TAZOP TAZOP TAZOMAX TAZOPIP PIP-TAZO PIP-TAZO PIPETAZO PIPETAZO MEPNAM
Adult Dose
Dose: 14000 to 21000 mg
Single Dose: 18000 (17500)
Frequency: As recommended.
Route: IV
Instructions: Daily in div.doses
Neonatal
Dose: 25 to 75 mg/kg
Single Dose: 50 (50)
Frequency: 6 hourly
Route: Intravenous
Instructions:
Paedriatic
Dose: 25 to 75 mg/kg
Single Dose: 50 (50)
Frequency: 6 hourly
Route: Intra Venous
Instructions: -
Characteristics
Piperacillin is the derivative of Piperacillin (Na). It is of Semi Synthetic origin and belongs to Beta Lactum. It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Penicillin pharmacological group.The Molecular Weight of Piperacillin (Na) is 539.50.
Contraindications
Piperacillin (Na)
Effects
The severe or irreversible adverse effects of Piperacillin (Na), which give rise to further complications include Prolongation of bleeding time.Piperacillin (Na) produces potentially life-threatening effects which include Anaphylaxis. which are responsible for the discontinuation of Piperacillin (Na) therapy.The symptomatic adverse reactions produced by Piperacillin (Na) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Diarrhea, Thrombophlebitis.
Indications
'Piperacillin (Na) is primarily indicated in conditions like Bacterial infections, Bone and joint infection, Complicated appendicitis, GI infections, Gonorrhoea, Hodgkin''s disease, Meningitis, Respiratory tract infections, Septicaemia, UTI.'
Interactions
Piperacillin (Na) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementArbekacinAtracurium (Besylate)Piperacillin may prolong the effect of atracurium.ModerateClose observation for respiratory depression and muscle weakness is recommended.CefoxitinChloramphenicolFloxacillin (Na)MethotrexateLarge doses of piperacillin elevate the serum concentration of methotrexate by competitively inhibiting its renal tubular secretion results in serious hematologic effects.MajorClosely monitor the serum concentration of methotrexate. Dose of methotrexate should be reduce if necessary.Leucovorin rescue should be available.ProbenecidTobramycinWarfarin (Na)Penicillin potentiate the risk of bleeding by inhibiting platelet aggregation.ModerateClosely monitor for INR and adjust the dose of warfarin when either start or discontinue the therapy with penicillin. Patient should report any sign of bleeding to physician. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
False +ve Coombs Test
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store Below 40°C. Inj (Reconstituted soln) Store at room temperature or refrigerator. Freezing is recommended. Use within I month(-15c) if freezed, within 1 week if refrigerated and within 24 hrs if kept at room temperature.
Warnings
Piperacillin should be used with caution in patients with any other illness or any allergy especially to penicillin or other antibiotics. It should be used only if clearly needed during pregnancy or lactation.
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