Pindolol

Pindolol is oral, nonselective, β-receptor antagonist with intrinsic sympathomimetic activity (ISA) (i.e., partial agonist activity). Pindolol is the β-blocker with the highest degree of ISA and nonselective antagonist qualities. The effect of ISA, as with β-blockade in general, can be selective or nonselective in nature. The partial agonist potential of Pindolol is greater for β 2- than β1-receptors, a characteristic that renders the drug a "vasodilatory" β-blocker. It was approved by the FDA in September 1982 for the treatment of hypertension. Like other β-adrenergic antagonists, it competes with adrenergic neurotransmitters (e.g., catecholamines) for binding at sympathetic receptor sites, similar to propranolol.

Brands
VISKALDIX
Adult Dose
Dose: 10 to 40 mg
Single Dose: 25 (25)
Frequency: 24 hourly
Route: PO
Instructions:
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Synthetic origin and belongs to Indole. It belongs to Beta adrenergic antagonist pharmacological group on the basis of mechanism of action and also classified in Antihypertensive Agents pharmacological group.The Molecular Weight of Pindolol is 248.30. Its pKa is 6.5, 8.3.
Contraindications
Pindolol is contraindicated in conditions like Bronchospasm,Haemorrhage,Heart block,Bradycardia.
Effects
Pindolol produces potentially life-threatening effects which include Cardiac failure, Hypoglycemia, Hypoglycemia, Bronchospasm, Ischemic heart disease. which are responsible for the discontinuation of Pindolol therapy.The symptomatic adverse reactions produced by Pindolol are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Fatigue, Insomnia, Nervousness, Muscle cramps, Edema, Muscle pain, nervousness.
Indications
Pindolol is primarily indicated in conditions like Angina, Cardiac arrhythmia, Hypertension, Supraventricular tachycardia.
Interactions
Pindolol is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAdrenalineCimetidine (HCl)Clonidine (HCl)DisopyramidePindolol decreases the clearance of disopyramide.Both agents have additive cardiac effecti.e.reduced cardiac output,hypotension and bradycardia.Coadministration may also prolong QT interval and QRS complexing widening. ModerateClose monitoring of cardiac output,blood pressure,heart rate and ECG is recommended.DisopyramideIndomethacinVerapamil (HCl) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Elevations of SGPT and SGOT Increased Alkaline Phosphatase Levels
Risks
Drug should not be given to Paediatrics, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Pindolol should be used with caution in diabetic patients and patients with liver and kidney impairments.
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