Pinacidil Monohydrate

Pinacidil Monohydrate is potassium channel opener. It is used in the managemnet of hypertension. It produces direct vasodilatation of the arterioles and reduces the blood pressure, and peripheral resistance but causes fluid retension.


Brands
Adult Dose
Dose: 0.178 to 0.535 mg/kg
Single Dose: 0.36 (0.3565)
Frequency: 12 hourly
Route: PO
Instructions: -
Neonatal
Paedriatic
Dose: Not use in children
Single Dose:
Frequency:
Route:
Instructions:
Characteristics
. It is of Synthetic origin and belongs to Pyridine. It belongs to Potassium Channel (ATP sensitive) opener pharmacological group on the basis of mechanism of action and also classified in Vasodilators pharmacological group.The Molecular Weight of Pinacidil Monohydrate is 263.40. Its pKa is 6.0, 10.8.
Contraindications
Pinacidil Monohydrate is contraindicated in conditions like Cardiac arrhythmia,Ischaemic heart disease,Cerebrovascular disease.
Effects
The severe or irreversible adverse effects of Pinacidil Monohydrate, which give rise to further complications include Tachycardia, Palpitation, Oedema.The symptomatic adverse reactions produced by Pinacidil Monohydrate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Palpitation, Tachycardia, Rashes, Increased intracranial pressure.
Indications
Pinacidil Monohydrate is primarily indicated in conditions like Bladder hyperactivity, Hypertension, Impotency, Renal hypertension.
Interactions
No data regarding the interactions of Pinacidil Monohydrate was found.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
Pinacidil monohydrate should be used with caution in patients with symptomatic ischaemic heart disease, cerebrovascular insufficiency, renal or hepatic (liver) dysfunction or pre-existing tachyarrhythmias.
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