Dose: 0.071 mg/kg
Single Dose: 0.071 (0.071)
Frequency: As recommended.
Route: IM
Instructions: As Required

Dose: 0.1 to 0.5 mg/kg
Single Dose: 0.3 (0.3)
Frequency: As recommended.
Route: Intra Venous
Instructions: Single Dose, As Required

. It is of Synthetic origin and belongs to Imidazole. It belongs to Alpha adrenergic antagonist pharmacological group on the basis of mechanism of action and also classified in Antihypertensive Agents pharmacological group.The Molecular Weight of Phentolamine (Mesylate) is 377.50. It is strongly acidic drug, 8.23% solution of the drug is isotonic and Its pKa is 7.7.

Phentolamine (Mesylate) is contraindicated in conditions like Hypotension,Obstructive cardiomyopathy,Cardiovascular disease,Cerebrovascular disease,Aortic stenosis.

Phentolamine (Mesylate) produces potentially life-threatening effects which include Hypotension. which are responsible for the discontinuation of Phentolamine (Mesylate) therapy.The signs and symptoms that are produced after the acute overdosage of Phentolamine (Mesylate) include Hypotension, Tachycardia, Cardiac arrhythmias, Hypoglycemia, Sweating, Headache, Excitation, Visual distrubances.The symptomatic adverse reactions produced by Phentolamine (Mesylate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea, Nausea and vomiting.

Phentolamine (Mesylate) is primarily indicated in conditions like Hypertension, Impotency, Phaeochromocytoma, Prophylaxis of NSAID-induced ulcer, and can also be given in adjunctive therapy as an alternative drug of choice in Skin necrosis.

Phentolamine (Mesylate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAdrenalineAdrenalineClonidine (HCl)Dobutamine (HCl)Protirelin These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Colorimetric measurement of 5-OH-Indoleaceticacid,false high values

Drug should not be given to Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Inj Store in refrigerator. Do not Freeze.

Phentolamine should not be given to patients with angina pectoris, ischaemic heart disease. Care should be taken in patients with peptic ulcer disease.