Phenoxymethylpenicillin (K)

Phenoxymethylpenicillin (K) is acid-resistant penicillin used orally. The actions, uses and adverse effects simmilar to that of benzylpenicillin. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular intervals of time throughout the day and night as prescribed. Phenoxymethylpenicillin (K) is important to take the drug for the full time period as prescribed. If you discontinue the drug it may result in ineffective treatment.

Brands
PENICILLIN V PENICILLIN V PENICILLIN V PENICILLIN V PENICILLIN V PENISOL V.K. PENVEE PENVEE
Adult Dose
Dose: 250 to 500 mg
Single Dose: 380 (375)
Frequency: 6 hourly
Route: PO
Instructions: As Required
Neonatal
Dose: 7.812 mg/kg
Single Dose: 7.8 (7.812)
Frequency: 6 hourly
Route: Intramuscular
Instructions:
Paedriatic
Dose: 12.5 mg/kg
Single Dose: 12 (12.5)
Frequency: 6 hourly
Route: Oral
Instructions: -
Characteristics
Phenoxymethylpenicillin (K) also known as Penicillin V. . It is of Semi Synthetic origin and belongs to Penicillanic Acid. It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.The Molecular Weight of Phenoxymethylpenicillin (K) is 388.50. Its pKa is 2.7.
Contraindications
Phenoxymethylpenicillin (K) is contraindicated in conditions like Penicillin hypersensitivity.
Effects
The severe or irreversible adverse effects of Phenoxymethylpenicillin (K), which give rise to further complications include Liver damage.Phenoxymethylpenicillin (K) produces potentially life-threatening effects which include Anaphylactic shock, Allergic reactions. which are responsible for the discontinuation of Phenoxymethylpenicillin (K) therapy.The symptomatic adverse reactions produced by Phenoxymethylpenicillin (K) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Diarrhea, Increased capillary fragility, Abdominal discomfort.
Indications
Phenoxymethylpenicillin (K) is primarily indicated in conditions like Bacterial infections, Endocarditis, Prophylaxis of rheumatic fever, Pruritus, Reversal of opioid-induced respiratory depression, Tonsillitis, Tonsillitis, otitis media.
Interactions
Phenoxymethylpenicillin (K) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAspirinCalamineMagnesium Oxides and HydroxidesNeomycinParomomycin (Sulphate)Zinc Oxide These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Biological tests for serum folate Serum electrophoresis Urinary Tests for Fructose, Aminolaevulinic acid, Oestrogens, 17-OH-Ketosteroids, protein & sugar Serum Tests for Uric Acid
Risks
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab, Syrup Store Below 40°C.
Warnings
History of allergy; renal impairment;
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