Pheniramine (Maleate)

Pheniramine (Maleate) is antihistamine. Pheniramine (Maleate) is effective in allergic rhinitis and allergic conjunctivitis, mild urticaria, angioedema, and in allergic reactions to blood and plasma in sensitive patients. Pheniramine (Maleate) is widely used as an ingredient in cold and cough preparations.


Adult Dose
Dose: 25 to 150 mg
Single Dose: 88 (87.5)
Frequency: 24 hourly
Route: May be given twice daily
Instructions:
Neonatal
Dose: 1.13 to 2.83 mg/kg
Single Dose: 2 (1.98)
Frequency: 24 hourly
Route: Intramuscular
Instructions: For above 6 month of child
Paedriatic
Dose: 0.726 to 1.816 mg/kg
Single Dose: 1.3 (1.271)
Frequency: 24 hourly
Route: Intra Muscular
Instructions: -
Characteristics
Pheniramine (Maleate) also known as Feniramin, Feniramin, Feniramin. . It is of Synthetic origin and belongs to Alkylamine. It belongs to H1-antagonist pharmacological group on the basis of mechanism of action and also classified in Antihistamine, Decongestant Combination pharmacological group.The Molecular Weight of Pheniramine (Maleate) is 356.40. Its pKa is 4.2, 9.3.
Contraindications
Pheniramine (Maleate) is contraindicated in conditions like Prostatic hypertrophy,Hypersensitivity.
Effects
The severe or irreversible adverse effects of Pheniramine (Maleate), which give rise to further complications include Hallucinations.The signs and symptoms that are produced after the acute overdosage of Pheniramine (Maleate) include Hyperthermia, Dry mouth, Hallucinations, Palpitations, Dizziness, Muscular weakness, Sedation, Toxic psychosis, Dermatitis.The symptomatic adverse reactions produced by Pheniramine (Maleate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Tachycardia, Tremors, Constipation, Nervousness, Dry mouth, Blurred vision, Sedation, Muscle weakness, Coordination disturbances, Lassitude, Urinary retention, nervousness.
Indications
Pheniramine (Maleate) is primarily indicated in conditions like Allergy, Angioedema, Angiooedema, Asthma, Conjuctivitis, Dermatitis, Eczema, Hay fever, Perennial rhinitis, Rhinitis, Urticaria, Vasomotor rhinitis, Vertigo.
Interactions
No data regarding the interactions of Pheniramine (Maleate) was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Below 25°C. Protect from Sunlight and Moisture.
Warnings
Pheniramine should be used only if clearly needed during pregnancy or lactation. It should be used with caution in patients with any eye problems, high blood pressure, diabetes, thyroid disorder, heart disease, asthma or allergies, especially to sulfites. should not be coadminister in patient who are already on a MAOI therapy because MAOI intensify or prolong the cholinergic effect of antihistamine and therefore pheniramine should be avoided in such conditions.
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