Dose: 0.714 to 2.142 mg/kg
Single Dose: 1.4 (1.428)
Frequency: As recommended.
Route: PO
Instructions: Maintenance, as required

Dose: 1 to 3 mg/kg
Single Dose: 2 (2)
Frequency: 24 hourly
Route: Oral
Instructions: -

Dose: 1 to 3 mg/kg
Single Dose: 2 (2)
Frequency: 24 hourly
Route: Oral
Instructions: -

. It is of Synthetic origin and belongs to Phenylindan. It belongs to Epoxide Reductase inhibitor pharmacological group on the basis of mechanism of action and also classified in Anticoagulants pharmacological group.The Molecular Weight of Phenindione is 222.20. Its pKa is 4.1.

Phenindione

The severe or irreversible adverse effects of Phenindione, which give rise to further complications include Fever, Skin rashes, Hypersensitivity reactions, Renal impairment, Skin necrosis.Phenindione produces potentially life-threatening effects which include Blood dyscrasias, Bleeding, Hepatitis. which are responsible for the discontinuation of Phenindione therapy.The symptomatic adverse reactions produced by Phenindione are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea, Skin reactions.

Phenindione is primarily indicated in conditions like Deep vein thrombosis, Prevention of embolism, Prevention of thrombosis, Prophylaxis after insertion of prosthetic heart valve, Prophylaxis and treatment of venous thrombosis and pulmonary embolism, Prophylaxis of embolisation in rheumatic heart disease and atrial fibrillation, Pulmonary embolism, and can also be given in adjunctive therapy as an alternative drug of choice in Rheumatic heart disease.

Phenindione is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholCarbamazepineCimetidine (HCl)Co-TrimoxazoleEstradiol (Valerate)MetronidazoleOxandroloneTheoretical potential for OXANDROLONE increasing the ANTICOAGULANT effect of PHENINDIONE. OxymetholoneLikely interaction of OXYMETHOLONE increasing the ANTICOAGULANT effect of PHENINDIONE. MajorPhenobarbitoneReviparin SodiumPhenindione may potentiate the action of Reviparin.SulphinpyrazoneVitamin K These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Red Coloration of Urine

Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Tab

Phenindione should be used with caution in patients with ulcers, unusual menstrual periods, diabetes, liver or kidney disease, high blood pressure, arthritis, thyroid problems, all recent infections, if have had recent surgery or of drug and food allergies. If patient have an illness that causes vomiting, diarrhea or fever for more than a few days, contact the doctor as these problems can change the effect of drug. Limit consumption of alcoholic beverages. Avoid sudden changes in dietary habits. Avoid ingesting unusual increases or decreases of foods high in Vitamin K (e.g.liver, cauliflower, cabbage, spinach and other green leafy vegetables, green tea, certain vegetables, cheeses and certain vitamin supplements). It is best to avoid strictly vegetarian diets that consist of foods high in vitamin K.Be extra careful to avoid injuries, because this medication can cause heavy bleeding. Be careful while brushing teeth and use an electric razor. It should not be used during pregnancy or lactation.