Antilymphocyte Immune Globulin

Antilymphocyte Immune Globulin may be added in immunosuppressant regimens in organ transplantation patient to treat acute rejection episode, Antilymphocyte Immune Globulin is also used in the treatment of aplastic anemia in patients unsuitable for bone marrow transplantation.


Brands
Adult Dose
Dose: 0.041 to 0.125 mg/kg.min
Single Dose: 0.083 (0.083)
Frequency: As recommended.
Route: IV Inf
Instructions: For 4 Hours
Neonatal
Dose: Not used in this age group
Single Dose:
Frequency:
Route:
Instructions:
Paedriatic
Characteristics
. It is of Natural origin and belongs to Protein. It belongs to Antibody pharmacological group on the basis of mechanism of action and also classified in Immune Globulin pharmacological group.
Contraindications
Antilymphocyte Immune Globulin is contraindicated in conditions like Allergy,Thrombocytopenia,Seizures,Parasite infection.
Effects
The severe or irreversible adverse effects of Antilymphocyte Immune Globulin, which give rise to further complications include Tachycardia, Hypotension, Febrile reactions.Antilymphocyte Immune Globulin produces potentially life-threatening effects which include Anaphylactoid reactions, Thrombocytopenia, Serum sickness. which are responsible for the discontinuation of Antilymphocyte Immune Globulin therapy.The symptomatic adverse reactions produced by Antilymphocyte Immune Globulin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Pruritus, Local thrombophlebitis, Erythema.
Indications
Antilymphocyte Immune Globulin is primarily indicated in conditions like Aplastic anemia, Bone marrow depletion of t cells, Rejection crises of transplanted organs.
Interactions
No data regarding the interactions of Antilymphocyte Immune Globulin was found.
Interfrence
False +ve Paul Bunnell Test
Risks
Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Ampule Store in refrigerator. Do not Freeze. Inj (reconstituted soln) Store in refrigerator. Use within 24 hrs if kept at room temperature.
Warnings
Antilymphocyte is not recommended for use during pregnancy or lactation. Immunosuppressant drug should not be given, where possible, to patients with acute infection, dosage reduction or withdrawal should be considered if infection develops, until the infection has been controlled. Blood counts and measurement of hemoglobin concentration should be carried out routinely, it help to predict the onset of bone marrow depression. It must be handled with great care and avoid contact with skin and eyes and should not be inhaled.
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