Pethidine (HCl)

Pethidine (HCl) is a synthetic narcotic analgesic. The actions and adverse effects similar to that of morphine. Pethidine (HCl) is used to relieve severe pain. It is also an antispasmodic. It can produce coma with danger of death on overdosage. Naloxone is a specific antagonist. Tolerance or physical dependence may occur after a long-term use.

Brands

PETHISCOT PETHIDINE

Adult Dose

Dose: 50 to 100 mg
Single Dose: 75 (75)
Frequency: 4 hourly
Route: IM,SC
Instructions:

Neonatal

Dose: 1 to 2
Single Dose: 1.5 (1.5)
Frequency: 4 hourly
Route: Intramuscular
Instructions:

Paedriatic

Dose: 0.5 to 0.2 mg/kg
Single Dose: 0.35 (0.35)
Frequency: 4 hourly
Route: Intra Muscular
Instructions: -

Characteristics

Pethidine (HCl) also known as Meperidine. . It is of Synthetic origin. It belongs to OPIATE agonist pharmacological group on the basis of mechanism of action and also classified in Analgesics and Anti-inflammatory Agents pharmacological group.The Molecular Weight of Pethidine (HCl) is 247.33.

Contraindications

Pethidine (HCl) is contraindicated in conditions like Asthma,Epilepsy,Phaeochromocytoma,Respiratory depression,Status epilepticus,Tetanus,Liver diseases,Hypersensitivity,Raised intracranial pressure,Supraventricular tachycardia,Kidney disease.

Effects

The severe or irreversible adverse effects of Pethidine (HCl), which give rise to further complications include Convulsions, Hallucinations, Vertigo, Tachycardia, Hypotension, Skin rashes, Myoclonus, GI symptoms, Hypertension, Dizziness.Pethidine (HCl) produces potentially life-threatening effects which include Coma, Respiratory depression, Convulsions, Hypotension, Dependence. which are responsible for the discontinuation of Pethidine (HCl) therapy.The signs and symptoms that are produced after the acute overdosage of Pethidine (HCl) include Bradycardia, Hypotension, Disorientation, Seizures, Dry mouth, Respiratory depression, Hypothermia, Hallucinations, Delirium, Tremor, Mydriasis, CNS depression, Cyanosis.The symptomatic adverse reactions produced by Pethidine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Drowsiness, Nausea, Vomiting, Constipation, Dry mouth, Urticaria, Pruritus, Erythema, Malaise, Hypersensitivity, Nausea and vomiting, Light headedness, Fibrosis, Twitching.

Indications

'Pethidine (HCl) is primarily indicated in conditions like Acute pain, Headache, Labor, Moderate to severe pain, Obsteteric analgesia, Obstetric pain, Pain, Parkinson''s disease; drug-induced extrapyramidal symptoms, Post-operative shivering, Pre-anaesthetic medication, Severe pain and tenderness in benign fibrocystic breast disease, Surgery, and can also be given in adjunctive therapy as an alternative drug of choice in All forms of epilepsy, Myoclonus.'

Interactions

Pethidine (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholBromazepamButorphanol (Tartrate)Chlorpromazine (HCl)Cimetidine (HCl)DisulfiramEtomidateFosphenytoinIotroxate (Meglumine)MethadoneNitrous OxidePerphenazinePhenobarbitonePhenytoin (Na)PrazepamPromethazine (HCl)RitonavirSelegiline (HCl)SibutramineTechnetium Tc-99m OxidronatePossible accumulation of technetium Tc 99m oxidronate at site[s] of injection of Pethidine (HCl).Thiopentone (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Interfrence

Risks

Drug should not be given to patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Storage

Inj Store Below 40°C. Protect from Sunlight.

Warnings

Pethidine should be used with caution in patients with supraventricular tachycardia, history of convulsive disorder or pulmonary depression. It should be used with caution during pregnancy.Donot drive as Pethidine may cause drowsiness. Pethidine should not be used for long term as its effectiveness may decrease. Use with caution in babies less than 1 month,in patients with breathing problems,convulsions or hypothyroidism.

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