Dose: 4 mg/kg
Single Dose: 4 (4)
Frequency: 24 hourly
Route: IM
Instructions: For 14 to 21 days

Dose: 4 mg/kg
Single Dose: 4 (4)
Frequency: 24 hourly
Route: Intra Muscular
Instructions: For 14 to 21 days

Dose: 4 mg/kg
Single Dose: 4 (4)
Frequency: 24 hourly
Route: Intra Muscular
Instructions: For 14 to 21 days

. It is of Synthetic origin and belongs to Amidine. It belongs to Antibiotic (Prokaryote DNA) pharmacological group on the basis of mechanism of action. The Molecular Weight of Pentamidine is 592.70. Its pKa is 11.4.

Pentamidine

The severe or irreversible adverse effects of Pentamidine, which give rise to further complications include Nephrotoxicity, Renal impairment, Pneumothorax, Hypoglycemia.Pentamidine produces potentially life-threatening effects which include Bradycardia, Hypoglycemia, Hypotension, Hypoglycemia, Cardiac Arrest, Cardiotoxicity, Myoglobinuria. which are responsible for the discontinuation of Pentamidine therapy.The symptomatic adverse reactions produced by Pentamidine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Nausea, Maculopapular rash, Pruritus, Hypotension, Flushing, Syncope.

Pentamidine is primarily indicated in conditions like Cutaneous leishmaniasis, Leishmaniasis, NSAID-associated gastric or duodenal ulcers, Pneumocystis carinii pneumonia, Trypanosomiasis, Visceral leishmaniasis.

Pentamidine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAdefovir DipivoxilAmiodarone (HCl)Risk of ventricular arrhythmia is increased by this combination due to dose related prolongation of QT interval.MajorThis combination should be avoided.AmisulprideIncreased risk of ventricular arrhythmias when Amisulpride given with Pentamidine. ADVICE: Avoid concomitant use or only undertaken with caution and apprppriate monitoring.Amphotericin BBoth drugs exert toxic effect on kidney result in increased nephrotoxicity.ModerateClosely monitor for renal function. Use an alternate antifungal in place of amphotericin B.Amphotericin BPossible increased risk of nephrotoxicity when Amphotericin given with Pentamidine.Close monitoring required.Foscarnet (Na)Foscarnet (Na)Sotalol (HCl)StavudineSuxamethonium (Cl)TerfenadineConcomitant use of these drugs increase the risk of ventricular arrythmiaModerateClinical monitoring is advisable.Thioridazine (HCl)Thioridazine and pentamidine both prolongs QT interval result in increased risk of ventricular arrythmia. MajorCoadministration of these agents is considered contraindicated.VORICONAZOLEAdditive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongationZalcitabineConcomitant use of these drugs increase the risk of pancreatitis.MajorClosely monitor for the signs of pancreatitis. Zalcitabine should be stopped. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Increased Values for LFTs

Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Inhalation Soln (freshly prepared) Store at room temperature. Protect from Sunlight. Use within 24 hrs if kept at room temperature. Inj (reconstituted soln) Store at room temperature. Protect from Sunlight. Use within 24 hrs if kept at room temperature.

Pentamidine should be used with caution in patients with asthma, allergies, high or low blood pressure, diabetes, high or low blood sugar, anemia or heart, kidney or liver disease, on a sodium- (salt-) restricted diet, low sugar (diabetic) diet or other restricted diet. It should be used with caution during pregnancy or lactation.