Anistreplase

Anistreplase is a thrombolytic drug. It consists of a complex of purified human plasminogen and becterial streptokinase that has been acylated to protect the active site of the enzyme. It prevents blood from clotting. Anistreplase is used in the treatment of deep vein thrombosis and pulmonary embolism. Anistreplase is effective in reducing the risk of death following an acute heart attack.it may produce allergic recatuions.

Brands
Adult Dose
Dose: 30 IU
Single Dose: 30 (30)
Frequency: As recommended.
Route: Slow IV
Instructions: As Required
Neonatal
Dose: Not recomended in this age group
Single Dose:
Frequency:
Route:
Instructions:
Paedriatic
Dose: Not Indicated in this Age Group
Single Dose:
Frequency:
Route:
Instructions:
Characteristics
. It is of Synthetic origin and belongs to Polypeptide. It belongs to Plasminogen Activator pharmacological group on the basis of mechanism of action and also classified in Plasma Protein Fractions and Thrombolytic Agent pharmacological group.The Molecular Weight of Anistreplase is 59042.30. Its pKa is 7.61.
Contraindications
Anistreplase is contraindicated in conditions like Hypertension,Peptic ulcer,Cardiac stroke,Vaginal bleeding,Chest compresion,Intracranial neoplasm,Diabetic retinopathy,Hemorrhagic diathesis.
Effects
The severe or irreversible adverse effects of Anistreplase, which give rise to further complications include Allergic reactions.Anistreplase produces potentially life-threatening effects which include Bleeding. which are responsible for the discontinuation of Anistreplase therapy.The signs and symptoms that are produced after the acute overdosage of Anistreplase include Hemorrhage.The symptomatic adverse reactions produced by Anistreplase are more or less tolerable and if they become severe, they can be treated symptomatically, these include Mild flushing, Shaking, Tight breathing.
Indications
Anistreplase is primarily indicated in conditions like Myocardial infarction.
Interactions
Anistreplase is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementTenecteplaseConcurrent use is usually not recommended but may be required in some cases. If both medicines are prescribed together, change of dose may be required. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Decreased plasminogen levelDecreased fibrinogen levelIncreased thrombin time
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj (reconstituted soln) Store at room temperature. Use within 30 min if kept at room temperature. Powder for Inj Store in refrigerator.
Warnings
Anistreplase should be used with caution in patients with bleeding, blood vessel abnormalities, brain tumor, history of stroke, recent surgery, extremely high blood pressure (200/120 or higher). This drug should be used with caution when the following conditions exist: child birth with in 10days, blood-clotting problems, retinal bleeding (recent) gastrointestinal or urinary tract bleeding (recent), ulcer, recent invasive medical procedure or any heart abnormalities.
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