Papaverine (HCl)

Papaverine (HCl) is alkaloid devoid of narcotic properties and was first described and extracted from opium in 1848 and later synthesized in 1990. Papaverine (HCl) is a hydrochloride salt of opium alkaloid that may be obtained from opium after separation of morphine or prepared synthetically. Chemically Papaverine (HCl) is 6, 7-dimethoxy-1-veratrylisoquinoline. Papaverine (HCl) is a smooth muscle relaxant, dilates the arteries and increase the blood flow to the obstructed region, especially in the treatment of cerebral and the peripheral ischemia associated with arterial spasm and myocardial ischemia complicated by arrhythmias. Papaverine (HCl) is administered orally, intravenously and intramuscularly.

Brands
SPASMOGIN SPASMOGIN
Adult Dose
Dose: 30 to 120 mg
Single Dose: 75 (75)
Frequency: As recommended.
Route: IV,IM,Intra Arterial
Instructions: 1-2 min. every 3 hrs.
Neonatal
Paedriatic
Dose: Safety not establushed
Single Dose:
Frequency:
Route:
Instructions:
Characteristics
. It is of Natural origin and belongs to Alkaloid. It belongs to Phosphodiesterase inhibitor pharmacological group on the basis of mechanism of action and also classified in Calcium Channel Blocker and Vasodilators pharmacological group.The Molecular Weight of Papaverine (HCl) is 375.90. Its pKa is 6.4.
Contraindications
Papaverine (HCl) is contraindicated in conditions like Glucoma,Myocardial infarction,Cardiac failure,Cardiac stroke,Heart block,Bradycardia,Liver diseases.
Effects
The severe or irreversible adverse effects of Papaverine (HCl), which give rise to further complications include Jaundice, Precipitation of glaucoma.The symptomatic adverse reactions produced by Papaverine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Drowsiness, Blurred vision.
Indications
Papaverine (HCl) is primarily indicated in conditions like Bronchospasm, Cerebral ischaemia, Cerebrovascular disease, Myocardial ischaemia, Pulmonary embolism, Smooth muscle spasm.
Interactions
Papaverine (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementLevodopaLevodopaNicotine These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab, Caps Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Papaverine should be used wit caution in patients of glaucoma.
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