Pamidronate (Disodium Pentahydrate)

'Chemically Pamidronate (Disodium Pentahydrate) is (3-amino-1-hydroxypropylidene) biphosphonic acid disodium salt pentahydrate. It reduces the blood calcium levels in tumour-induced hypercalcemia to has a slow onset of action so is not suitable for initial treatment of severe hypercalacaemia . It inhibits resorption, so is used to treat Paget''s disease of bone. Pamidronate (Disodium Pentahydrate) is also used in the treatment of osteoporosis, to reduce bone pain associated with myeloma and breast cancer. Pamidronate (Disodium Pentahydrate) is prepaed by chemical synthesis and available in any combination preparations. Pamidronate (Disodium Pentahydrate) is administered intravenously.'

Brands
AREDIA AMINOMUX AMINOMUX AMINOMUX AMINOMUX PAMISOLE OSTEOPAM OSTEOPAM PAMIDRIA PAMIDRIA PAMIDRIA
Adult Dose
Dose: 30 to 90 mg
Single Dose: 60 (60)
Frequency: As recommended.
Route: IV
Instructions: Once or As Required
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Biphosphate. It belongs to Osteoclast inhibitor pharmacological group on the basis of mechanism of action and also classified in Antidotes pharmacological group.The Molecular Weight of Pamidronate (Disodium Pentahydrate) is 367.00. Its pKa is 0.1, 6.2, 10.9.
Contraindications
Pamidronate (Disodium Pentahydrate) is contraindicated in conditions like Hypersensitivity to any component of product.
Effects
The severe or irreversible adverse effects of Pamidronate (Disodium Pentahydrate), which give rise to further complications include Fever, Acute phase response.The symptomatic adverse reactions produced by Pamidronate (Disodium Pentahydrate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Hypophosphatemia, Hypocalcemia.
Indications
Pamidronate (Disodium Pentahydrate) is primarily indicated in conditions like Bone (pagets) disease, Hypercalcaemia, Osteoporosis, Thyrotoxicosis, and can also be given in adjunctive therapy as an alternative drug of choice in Bone metastasis.
Interactions
No data regarding the interactions of Pamidronate (Disodium Pentahydrate) was found.
Interfrence
Hematocrit Value Complete blood cell count
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj (reconstituted soln) Store in refrigerator.
Warnings
Pamidronate should be used with caution in patients with any pre-existing kidney disease or any allergy. It should not be used during pregnancy.
Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.