Oxytetracycline (Dihydrate)

Oxytetracycline (Dihydrate) is a naturally occuring tetracycline, produced by Streptomyces rimosis. Like other tetracycline it has a broad spectrum of activity.it was introduced in 1950. Effective against a wide range of both gram positive and gram negative organisms.The main mechanism of action is on protien synthesis. In addtion to its antibiotic activity Oxytetracycline (Dihydrate) is also a chelating agent and will chelate Ca, Mg or Al ions in the gut. Oxytetracycline (Dihydrate) is administered orally and intramuculalrly. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular intervals of time throughout the day and night as prescribed. Oxytetracycline (Dihydrate) is important to take the drug for the full time period as prescribed. Discontinuation of the drug may result in ineffective treatment.


Adult Dose
Dose: 250 to 500 mg
Single Dose: 380 (375)
Frequency: 6 hourly
Route: PO
Instructions:
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
Oxytetracycline (Dihydrate) also known as Glomycin, Glomycin, Glomycin, Glomycin, Glomycin. Oxytetracycline HCL is the derivative of Oxytetracycline (Dihydrate). It is of Semi Synthetic origin and belongs to Tetracycline. It belongs to Antibacterial (Proetin synthesis inhibitor) pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Tetracycline Derivative pharmacological group.The Molecular Weight of Oxytetracycline (Dihydrate) is 496.50. Its pKa is 3.3, 3.7, 9.1.
Contraindications
Oxytetracycline (Dihydrate) is contraindicated in conditions like Systemic lupus erythematosus.
Effects
The severe or irreversible adverse effects of Oxytetracycline (Dihydrate), which give rise to further complications include Renal failure.Oxytetracycline (Dihydrate) produces potentially life-threatening effects which include Staphylococcal enterocolitis, Fluminating diarrhea. which are responsible for the discontinuation of Oxytetracycline (Dihydrate) therapy.The signs and symptoms that are produced after the acute overdosage of Oxytetracycline (Dihydrate) include Vomiting, Coma.The symptomatic adverse reactions produced by Oxytetracycline (Dihydrate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Anorexia, Diarrhea, Maculopapular rash, Dysphagia, Enterocolitis, Erythematous rash, Esophagitis, Leukopenia, Bulging of fontanelle, Esophageal ulceration.
Indications
'Oxytetracycline (Dihydrate) is primarily indicated in conditions like Acne, Actinomycotic mycetoma, Amoebic dysentry, Biliary tract infections, Brucellosis, Chlamydial infections, Cholera, Fever, Gonorrhoea, Malaria, Melioidosis, Pneumonia, Q Fever, Respiratory tract infections, Rickettsiae, Rosacea, Syphilis, Urinary tract infection, Whipple''s disease, and can also be given in adjunctive therapy as an alternative drug of choice in Acne rosacea, Acne vulgaris, Long-term treatment of healed gastro-oesophageal reflux disease.'
Interactions
Oxytetracycline (Dihydrate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAmphotericin BCalcium GluconateClavulanic AcidEmetine (HCl)IchthammolNeostigminePyridostigmine (Br)Riboflavin (Vitamin B2)Riboflavin interferes with the absorption and effectiveness of tetracyclines.Sodium BicarbonateVitamin K These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Hingerty method for Urinary Catecholamine Measurements Urinary Urobilinogen Excretion Test Levels
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Caps Store Below 40°C. Protect from Sunlight and Moisture. Eye Drops Store in a well closed container, Below 40°C. Do not Freeze. Protect from Sunlight and Moisture.
Warnings
Oxytetracycline should be used with caution (if contains tartrazine) in patients with aspirin hypersensitivity, because it may cause allergic reactions (including bronchial asthma). Take appropriate measures if secondary infection occurs. Perform periodic lab evaluation of organ system (e.g. liver or kidney) in case of long term therapy.
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