Oxymetazoline (HCl)

Oxymetazoline (HCl) is a sympathomimetic amine of the imidazoline class.Oxymetazoline (HCl) is a direct agonist at alpha-adrenergic receptors with no action on beta-adrenergic receptors. Oxymetazoline (HCl) is used as a nasal decongestant in allergic rhinitis, and also as a ocular decongestant in allergic conjunctivitis (whether seasonal or perennial). Chemically Oxymetazoline (HCl) is 3-[(4,5-dihydro-1H-imidazol-2-yl) methyl]-6-(1,1-dimethylethyl)-2,4-dimethylphenol hydrochloride. Oxymetazoline (HCl) is available for nasal and opthlamic administration.

Brands
OXYLIN EYE DROPS RINERGE
Adult Dose
Dose: 0.09%
Single Dose: 0.09 (0.09)
Frequency: 12 hourly
Route: Intra Nasal
Instructions: 1-2 drops in each nostril.
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose: 0.025 to 0.035 mg
Single Dose: 0.03 (0.03)
Frequency: 12 hourly
Route: Nasal
Instructions: For children above 5 yrs.
Characteristics
belongs to Imidazoline. It belongs to Alpha-2 adrenergic agonist pharmacological group on the basis of mechanism of action and also classified in Nasal Decongestants and Syumpathomimetic pharmacological group.The Molecular Weight of Oxymetazoline (HCl) is 296.80. It is weakly acidic drug, 4.92% solution of the drug is isotonic.
Contraindications
Oxymetazoline (HCl) is contraindicated in conditions like Narrow-angle glaucoma.
Effects
The severe or irreversible adverse effects of Oxymetazoline (HCl), which give rise to further complications include Rhinitis medicamentosa.The signs and symptoms that are produced after the acute overdosage of Oxymetazoline (HCl) include Hypotension, Sedation.The symptomatic adverse reactions produced by Oxymetazoline (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Stinging on application, Dryness of eye.
Indications
Oxymetazoline (HCl) is primarily indicated in conditions like Ocular congestion, Otitis media, Rhinitis, Sinusitis, and can also be given in adjunctive therapy as an alternative drug of choice in Conjuctivitis.
Interactions
No data regarding the interactions of Oxymetazoline (HCl) was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Nasal Spray, Nasal Drops Store Below 40°C. Protect from Sunlight and Heat.
Warnings
Use topical decongestant (oxymetazoline) only in acute conditions, not longer than 3 to 5 days. It should be use sparingly in all patients, especially in infants, children and in cardiac patients.
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