Oxprenolol (HCl)

Oxprenolol (HCl) is a non-selective β receptor blocking agent with some partial agonist activity. Chemically Oxprenolol (HCl) is 1-[2-(allyloxy) phenoxy]-3-isopropylaminopropan-2-ol hydrochloride. Oxprenolol (HCl) is antihypertensive agent and used in the management of hypertension, angina pectoris, also in anxiety disorders.

Brands

Adult Dose

Dose: 0.285 to 2.285 mg/kg
Single Dose: 1.3 (1.285)
Frequency: 8 hourly
Route: PO
Instructions: -

Neonatal

Dose: 1 mg/kg
Single Dose: 1 (1)
Frequency: 8 hourly
Route: Oral
Instructions: -

Paedriatic

Dose: 1 mg/kg
Single Dose: 1 (1)
Frequency: 8 hourly
Route: Oral
Instructions: -

Characteristics

. It is of Synthetic origin and belongs to Benzene. It belongs to Beta adrenergic antagonist pharmacological group on the basis of mechanism of action and also classified in Antihypertensive Agents pharmacological group.The Molecular Weight of Oxprenolol (HCl) is 301.80. Its pKa is 9.5.

Contraindications

Oxprenolol (HCl) is contraindicated in conditions like Bronchospasm,Cardiac failure,Haemorrhage,Bradycardia,Low cardiac output.

Effects

Oxprenolol (HCl) produces potentially life-threatening effects which include Bradycardia, Hypoglycemia, Hypotension, Bronchospasm. which are responsible for the discontinuation of Oxprenolol (HCl) therapy.The symptomatic adverse reactions produced by Oxprenolol (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Lethargy, Wheezing, Coolness of extremities.

Indications

Oxprenolol (HCl) is primarily indicated in conditions like Angina, Cardiac arrhythmia, Hypertension, Obstructive cardiomyopathy, To prevent 1st occurrence of neural tube defect, To prevent recurrence of neural tube defect, and can also be given in adjunctive therapy as an alternative drug of choice in Anxiety.

Interactions

Oxprenolol (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAdrenalineClonidine (HCl)Ergometrine (Maleate)simultaneous use of ergometrine and b- adrenoceptor blocker may increase peripheral vascular resistance. increase risk of vascular occlusion . simultaneous use of ergometrine and b- adrenoceptor blocker should be avoidedHydralazine (HCl)IndomethacinLignocaineVerapamil (HCl) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Interfrence

False +ve Fluorometric Readings in Urine Cortisol Determination

Risks

Drug should not be given to Paediatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Storage

Tab

Warnings

Oxprenolol should be used with caution in diabetic patients or patients with liver or kidney impairments.

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