Amsacrine

Amsacrine is the antineoplastic agent, also called anticancerou drug. Amsacrine is a 9-anilinoacridine derivative. Amsacrine is effective in the treatment of different cancers to slow or stop the growth of abnormal cells. Amsacrine is used in combination with different anticancerous drugs to obtain most excellent therapeutic effects and to minimize unwanted effects or toxicities.

Brands
Adult Dose
Dose: 375 to 625 mg/sq.meter
Single Dose: 500 (500)
Frequency: 24 hourly
Route: IV
Instructions: For 5 Days, Repeated after 3-4 Weeks
Neonatal
Paedriatic
Characteristics
Amsacrine also known as Acridinyl Anisidide. . It is of Synthetic origin and belongs to Sulphonamide. It belongs to DNA Strand Breakage pharmacological group on the basis of mechanism of action and also classified in Chemotherapeutic Regimens and Antineoplastic Agent pharmacological group.The Molecular Weight of Amsacrine is 393.50.
Contraindications
Amsacrine is contraindicated in conditions like Hypokalaemia,Pregnancy,Breast feeding.
Effects
The severe or irreversible adverse effects of Amsacrine, which give rise to further complications include Anemia, Thrombocytopenia, Mucositis, Hepatotoxicity.Amsacrine produces potentially life-threatening effects which include Bone marrow aplasia, Arrhythmias. which are responsible for the discontinuation of Amsacrine therapy.The signs and symptoms that are produced after the acute overdosage of Amsacrine include Bone marrow suppression.The symptomatic adverse reactions produced by Amsacrine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Vomiting, Diarrhea, Mucositis, Abdominal pain, Rashes, Myelosuppression, Stomatitis, Perirectal abscess, Confusion, Urticaria, Pruritus.
Indications
Amsacrine is primarily indicated in conditions like Myelogenous leukaemia, Refractory acute non-lymphocyte leukemia.
Interactions
No data regarding the interactions of Amsacrine was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store Below 25°C. Protect from Sunlight.
Warnings
Amsacrine is not recommended for use during pregnancy or lactation. Immunosuppressent drug should not be given, where possible, to patients with acute infection, dosage reduction or withdrawal should be considered if infection develops, until the infection has been controlled. Blood counts and measurement of hemoglobin concentration should be carried out routinely, help to predict the onset of bone marrow depression. It must be handled with great care and avoid contact with skin and eyes and should not be inhaled.
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