Ouabain

Ouabain is a cardiac glycoside, consists of a molecule of rhamnose linked to a steroid nucleus, used in the treatment of arrythmias and heart failure. Ouabain is obtanied principally from the seeds of Strophanthus gratus. The actions on the heart similar to those of Digoxin, but only reliably active when given parentrally when the onset of action is more rapid than for digoxin. It has +ve inotropic effect on heart i.e increase force of muscular contraction .

Brands
Adult Dose
Dose: 0.004 mg/kg
Single Dose: 0.004 (0.004)
Frequency: As recommended.
Route: IV
Instructions: Initial
Neonatal
Paedriatic
Characteristics
It belongs to Sodium Potassium atpase inhibitor pharmacological group on the basis of mechanism of action and also classified in Anti arrhythmic agents pharmacological group.The Molecular Weight of Ouabain is 728.80.
Contraindications
Ouabain is contraindicated in conditions like Heart block,Aortic valve disease,Acute myocarditis,Cardiomyopathy,Cor pulmonale,Pericarditis.
Effects
The symptomatic adverse reactions produced by Ouabain are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Nausea and vomiting, Pulse irregularities, Heart block.
Indications
Ouabain is primarily indicated in conditions like Atrial fibrillation, Atrial flutter, Cardiac arrhythmia, Left ventricular failure, Ventricular arrhythmias.
Interactions
Ouabain is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementFrusemide or Furosemide These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Apparent cons. of 17-hydoxy-corticosteriod in urine
Risks
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Protect from Sunlight.
Warnings
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