Omeprazole

Omeprazole is a an oral antiulcer agent. Omeprazole is characterized as a gastric acid pump inhibitor because it blocks the final step of gastric acid production. It has a long duration of action and is very potent, allowing for once-daily administration. Despite its potency, it must be used in combination with antibiotics to be effective against Helicobacter pylori. Due to concern regarding long-term use, it was originally approved by the FDA in September 1989 for acute treatment only. In December 1994, an FDA advisory committee recommended it be approved for maintenance therapy of healed erosive esophagitis. In April 1996, it was approved for the treatment of H. pylori-associated duodenal ulcer. Belongs to a new class of antisecretory agents, the substituted benzimidazoles, which suppress gastric acid secretion by inhibiting the H+/K+ ATPase enzyme system of parietal cells. it, following activation in an acidic pH, binds irreversibly to the H+/K+ ATPase pump on the secretory surface of the parietal cell membrane. Subsequently, the secretion of hydrogen ions into the gastric lumen is inhibited. it inhibits both basal and stimulus-induced acid secretion.


Brands
XEROSEC OMEPRAL UZOL RAMEZOL RAMEZOL ZAPROLE PLUS ZAPROLE OPARA CAP ESELAN ESELAN IN HELEZOL HELEZOL HELEZOL CAPZOL CAPZOL PROCEPTIN OMESEC ZEPEP OMEZOL OMEZOL OMEZOL OMEZOL LOSEC LOSEC ZOLBI ZOLBI PROLOC FAAST FAAST FAAST Z-PRAL EFOME OMEFAST PLUS OMEFAST ZEGNA LAPIZOLE ULSIVE OPICAP ACIZOL AMPRA AMPRA AMPRA AMPRA CIBRA OMEGA OMEGA OMEGA OMEGA OMEGA OMEGA OMEGA OMEGA RAPID OMEGA RAPID OMEGA RAPID OMEGA RAPID HELICURE OMRPA-T NONCID PROZA GARD FEDAZOL MEPCID OMEPEC VALUPRAZOLE MEPSAL MEPSAL PROTOLE PROTOLE OPEPZOLE OPEPZOLE OPEPZOLE OPEPZOLE OMEZONATE OMEZONATE OMEZONATE OMEZONATE ZOLACID RISEK INSTA RISEK INSTA RISEK RISEK RISEK OMP TROLOC OMEZAC PLUS OMEZAC PLUS OMEZAC PLUS OMEZAC PLUS RULING PLUS RULING PLUS RULING PLUS RULING PLUS RULING RULING LOZENA MEP-B MEP-B MEP-B MEP-B ETIPRO CIPRO CIPRO CIDPRO CIDPRO CIMOZOL IRZAZOLE KLOFIX PYMER OMIT OPRAZOLE SANTE PLUS SANTE PLUS SANTE SANTE OMEDOC INGIS RETROT PRO HIBIT ALPAZOL OMED LOZIP XOPRA XOPAC XOPRA PLUS OZOP SB OZOP SB PEPZOL LOPROT LOPROT PROBITOR PROBIOTOR OMENEU LOZAL ORCAP VINZOLE VINZOLE OBSOZOLE NENSEC OMELCID OMECER ZOLTAR INSTA ZOLTAR INSTA ZOLTAR INSTA ZOLTAR INSTA ZOLTAR ZOLTAR NILCID WISPRAZOL WISPRAZOL PRAZOL RELEVOLE RELEVOLE OMEPRAZEN OPIZOL OPIZOL GARAZOLE HEALER LOC-H PP. ZOLE LOZAMEP OMCAP EMPEROLE POAMI TEPH-20 TEPH TEPH TEPH TEPH TEPH OSYD-20 OMEPRAZAL OMEPRAZAL ANZO GLAVERAL XIFT XIFT VIFY PRENAT PRENAT PRENAT PRENAT FORTIFY LOMPER ZULCID OMCED-S OMCED-S ZEGRID NOUL HYPOCID PERL OPRIL OMERA OMERA SANAMIDOL CISEC CISEC BENZIM BENZIM BENZIM BENZIM ZAMPRA OMNIMINT OMNIMINT OMRAZO ENCID ENCID ENCID ENCID ENCID ENCID NEUSEC PLUS NEUSEC PLUS NEUSEC PLUS NEUSEC PLUS NEUSEC MEPRAZOL MEPRAZOL MEPRAZOL MEPRAZOL BIOS BIOS BIOS BIOS AKSOZOL NORAN NORAN ULSAZOLE PIXEL DELSER KARZOLE DELPROZ ZOLAT ZOLAT OMEP MINE O-LEX ZOLOMP HAMAZOL BERIZOLE BERIZOLE OME MED OMIPEN OMPIZOL OZEM ZOLPRO ZOLPRO ZOLPRO NOCTIS UL-RID OMEPRAVAL OMEPRAVAL OMEPRAVAL OMEPRVAL OM OM SEGAZOLE RAZOLE PLUS RAZOLE EPENT O-CID O-CID OMCOOL OMESZOLE OMAK OPZA MOPIRIXL OZOPMAX OZOPMAX OZOP ACIDRIN CRIZOL OMEPRAGEN PPI-20 K-OM K-OM OLTRIX OMEFILL INFUSION OMEFILL CAPSULE SUNDER PROMY MACOMEZ MACOMEZ OMEHEIM OMOL BOLD BOLD MEPRASCOT MEPRASCOT MEPRASCOT ZALAIM OMEPRAFAST OMEPRAFAST B CAP BEPRAZOLE BEPRAZOLE ZOGER AIMPRA OMEPID OMEPID OMREL PLUS OMREL PLUS OMREL PLUS OMREL OMREL OMETON ZORAL ZORAL MEPROLIVE MEPROLIVE PROPI OPRIME OMELINZ SECOMEP OPERITEC OMEPRAZOLE ZEGERID PLUS OHAB ZEGERID ANTRA ANTRA AMAZOLE OMAPREN FYMEZOLE NOAZOL D NOAZOL NOAZOL PLUS NOAZOL PLUS NOAZOL PLUS NOAZOL PLUS MEGAZOLE VAPRA OMPIL OMESTOCK NEUSAC TEMEROL PRISMA PRISMA PROPRAZOL NOVISAC NOVISAC LOCOREX ANMOL ANMOL FEGRAN ADZOL ZOGLIT ZOGLIT OMZE MEBRAZOLE MEBRAZOLE RE-ZOOL OMENZA DANTONE NURZOL ZOPROL OMEC OMEC OMEC ALOMEP UNIPRAZOLE OMNAT PLUS OMNAT PLUS OMNAT PLUS OMNAT PLUS OMCURA OMCURA OMNAT RAZOMEP MAAG FORMAGA PREZIT RAPID EPRACO EPRACO EPRA EPRA HANZOL HANSOL HANSOL FARMPRA OMETOR COOZIP OMEYZ OZKER AMOP MEDIZOLE MEDIPRZOLE WINPRO OZOWIN O-CARB ESOWIN ESOWIN MEPRAWIN MEPRA METZAN OPEROS OPEROS ZOLCARE ZOLCARE OPRA HOMZE DYSOZOL DYSOZOL OMPER MESO OMETRO AZITRIX WIZOL WIZOL REZAL REZAL IZMEPRA OMEL OMEL OMEPEFLORE OMIGOOD OMIGOOD OPERA OMEROWN DINAAR OMATOLE OMENATE OMENATE OMENATE-D OMENATE-D O-MAAG MAGFAST D MAGFAST D GAMP MAGSER MAGSER MAGSER MAGFAST MAGFAST NAFZOLE G-CID G-CID XEMPRA OMRAGIL OMRAGIL OMNIA BROMEP BROMEP OMEPROWAN PLUS OMEPROWAN PLUS OMEPROWAN PLUS OMEPROWAN PLUS OMEPROWAN OMEPROWAN OMEDAY OMEDAY OMI-B OMI-B OMI-B OMI-B TIMEZOL TIMEZOL MAPRA MAPRA LINOPRA HUPRA PRAMAX PRAMAX PRAMAX PRAMAX OMEPAK WELPO MEPRAZOLE OWEL ZEPMOL BIMEP OGNEN ERIFASS ERIFASS ERIFASS D ERIFASS D MEPRAGEN ZOGITAL SAFOMEP SAFOMEP OMEP OMEGUT OMEGUT STOMEP STOMEP ZOLCER OMEZOMAN OMEZOMAN ACEZOLE ACEZOLE SYDROL ZES OMEZ OPALEX REDULEX BRIZOLE MEPZAN MEPZAN OMEXIA OMEXIA RAXAR MARK MARK ROMEPRAZOLE SYNZOLE SYNZOLE OMSOD OMSOD OMSOD OMSOD PZOLE PEPRAZOLE NORANI OMRAZOLE WEPRAZOL OMEBRAIN ZOLAPT PROCED OMEPZA
Adult Dose
Dose: 20 to 40 mg
Single Dose: 30 (30)
Frequency: 24 hourly
Route: PO
Instructions: For 4 weeks.
Neonatal
Paedriatic
Characteristics
Omeprazole also known as Proton pump Inhibitor. . It is of Synthetic origin and belongs to Benzimidazol. It belongs to H/K Atpase proton pump inhibitor pharmacological group on the basis of mechanism of action and also classified in Antacids pharmacological group.The Molecular Weight of Omeprazole is 345.40. Its pKa is 4.0, 8.7.
Contraindications
Omeprazole
Effects
The severe or irreversible adverse effects of Omeprazole, which give rise to further complications include Interstitial nephritis.Omeprazole produces potentially life-threatening effects which include Anaphylaxis. which are responsible for the discontinuation of Omeprazole therapy.The signs and symptoms that are produced after the acute overdosage of Omeprazole include Tachycardia, Drowsiness, Headache.The symptomatic adverse reactions produced by Omeprazole are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Dizziness, Headache, Fatigue, Nausea, Diarrhea, Myalgia, Constipation, Insomnia, Abdominal pain, Dry mouth, Urticaria, Pruritus, Photosensitivity, Skin rash, Impotence, Depression, Arthralgia, Myopathy, Gynecomastia, Agitation, Dry mouth, dizziness.
Indications
Omeprazole is primarily indicated in conditions like Acid reflux disease (long-term management), Benign gastric and duodenal ulceration, Benign gastric and duodenal ulcers, Benign gastric ulcer associated with H.pylori, Duodenal errosions, Duodenal or benign gastric ulcer associated with H.pylori, Duodenal ulcer, Duodenal ulcer associated with h. Pylori, Gastric acid reduction during anaesthesia, Gastric acid reduction during general anaesthesia, Gastric ulcer, Gastro-esophageal reflux disease, Gastro-oesophageal reflux disease, Gastro-oesophageal reflux disease (refractory to other treatment), Maintenance of recurrent duodenal ulcers, Non-ulcer dyspepsia, NSAID-associated gastric and duodenal ulcers, NSAID-associated gastric and duodenal ulcers (prophylaxis), NSAID-associated gastric and duodenal ulcers and duodenal errosions, NSAID-associated gastric or duodenal ulcers, NSAID-associated gastric or duodenal ulcers (prophylaxis), Prevention of relapse in duodenal ulcer, Prophylaxis for NSAID-associated gastric and duodenal ulcers, Prophylaxis of acid aspiration, Reflux oesophagitis, Resistant ulcers, Severe or recurrent duodenal and gastric ulcertion, Zollinger-ellison syndrome, and can also be given in adjunctive therapy as an alternative drug of choice in Acid aspiration syndrome prevention, GI bleeding.
Interactions
Omeprazole is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlprazolamCeftibutenCilostazoleClarithromycinomeperzole is used in combination with clarithromycin to treat patients with ulcer by helicobacter pylori.ClobazamClopidogrelCyanocobalaminomeperzole decrease the absorption of CyanocobalamineDiazepamomeperzole decrease the clearance of diazepamDigoxinOmeprazole may inhibit the absorption of digoxinMinorMonitor serum digoxin levels.EscitalopramHalazepamHydroxocobalaminLansoprazoleLodoxamide TromethamineMethotrexateOmeprazole increases the serum concentration of methotrexate by inhibiting its active tubular secretion through renal H+/K+ ATPase pumps.ModerateOmeprazole therapy should discontinue several days before administration of methotrexate. Closely monitor the serum level and toxicity of methotrexate. Use H2 antagonist as an alternative.NelfinavirPhenytoin (Na)omeperzole decrease the clearance of phenytoinRiluzoleOmeprazole could increase the rate of riluzole elimination. Sodium DiatrizoateShould not be use concurrently without informing doctor.TheophyllineOmeprazole may inhibit the absorption of theophyllineTocilizumabToclizumab increases the exposure of OmeprazoleVORICONAZOLEVoriconazole increases the effect and toxicity of omeprazoleWarfarin (Na)omeperzole decrease the clearance of warfarin These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Caps Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Omeprazole should be used with caution in patients with liver or kidney disease. It should be used only when clearly needed during pregnancy. Avoid use during lactation. In elderly these is no problem in clinical use to data.
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