Olsalazine (Na)

Olsalazine (Na) is a sulfa free drug based on 5-aminosalicyclic acid. It consist of 5-aminosalicylic acid joined together through an azo bond. It acts locally in the colon by delivery of two 5-ASA molecules after splitting of the azo-bond to relieve the inflammation. Olsalazine (Na) is used to treat and prevent relapse of ulcerative colitis. Olsalazine (Na) is prepared by chemical syhthesis. Olsalazine (Na) is administered orally.

Brands
Adult Dose
Dose: 21.428 to 42.857 mg/kg
Single Dose: 32 (32.1425)
Frequency: 24 hourly
Route: PO
Instructions: -
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose: 150 to 300 mg/kg
Single Dose: 220 (225)
Frequency: 24 hourly
Route: Oral
Instructions: For above 2 Yrs of children
Characteristics
Olsalazine (Na) also known as Azodisal Na. . It is of Synthetic origin and belongs to Aminosalicylic Acid. It belongs to Ulcerative Colitis remedies (GI) pharmacological group on the basis of mechanism of action and also classified in Analgesics and Anti-inflammatory Agents and Antipeptic Ulcerant pharmacological group.The Molecular Weight of Olsalazine (Na) is 346.20. Its pKa is 2.07, 11.5.
Contraindications
Olsalazine (Na) is contraindicated in conditions like Hypersensitivity.
Effects
The severe or irreversible adverse effects of Olsalazine (Na), which give rise to further complications include Pancreatitis.Olsalazine (Na) produces potentially life-threatening effects which include Bone marrow suppression, Lupus like Syndrome. which are responsible for the discontinuation of Olsalazine (Na) therapy.The symptomatic adverse reactions produced by Olsalazine (Na) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Loose stools, Dizziness, Headache, Nausea, Alopecia, Abdominal pain, Rashes, Arthralgia, Light headedness, Alopecia, dizziness, Diarrhoea, rashes.
Indications
Olsalazine (Na) is primarily indicated in conditions like Ulcerative colitis.
Interactions
No data regarding the interactions of Olsalazine (Na) was found.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Caps Store Below 40°C. Protect from Sunlight and Moisture. Store Between 15°C-30°C.
Warnings
Olsalazine should be used only if clearly needed during pregnancy. It should be used with caution in patients with allergies especially to aspirin or aspirin-like medications or if have a history of nasal polyps or asthma. It can increase sensitivity to sunlight, so avoid prolonged sun exposure, wear protective clothing and use a sunscreen.
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