Nystatin

Nystatin is antifungal agent obtained from Streotomyces noursei. It was one of the first polyene antibiotic of undetermined structure, discovered and used clinicaly. It acts as a fungistatic and fungicidal and active against most Candida species. Nystatin is a mixture of four different tetranes, primarily it A1, along with two other tetranes A2 or A3 and polyfungin B. Nystatin is very toxic for parentral administration and is only used topically.

Brands
POLYGYNAX CLOBEDERM-NN MYCONIL MYCONIL OCTAPLAS-NN OCTAPLAS-NN NYLOSIN CORTIDERM-NN DERMOVATE-NN KENACOMB KENACOMB KENACOMB KENACOMB SALINOSE BETACIN PLUS BETACIN PLUS BETACIN PLUS BETACIN PLUS NYSTRIN TERGYNAN O-NYSTAT O-NYSTAT ULTICOMB ULTICOMB PRIMOVATE NN PRIMOVATE NN NILSTAT NILSTAT NILSTAT NILSTAT XECOMB FLOGOCID FLOGOCID FLOGOCID FLOGOCID ZIRITH ZIRITH ZIRITH ZIRITH BUFAC BUFAC MICOSTATIN MICOSTATIN MYSTATE NISTORAL NYSTA DAVISTIN CLOBET NN MONILSTAT NESTATEN DANSTATIN-NN GRAYNIS NIMSTAT NIMSTAT NIMSTAT CARA-MAC CARA-MAC NYST NATIN
Adult Dose
Dose: 100000 IU
Single Dose: 100000 (100000)
Frequency: As recommended.
Route: Buccal
Instructions: Preferably 2-4 times a day.
Neonatal
Paedriatic
Dose: 100000 IU/gm
Single Dose: 100000 (100000)
Frequency: 8 hourly
Route: Buccal
Instructions: -
Characteristics
Nystatin also known as Fungicidin, Fungicidin. . It is of Semi Synthetic origin and belongs to Polyene. It belongs to Antifungal Agent, Topical pharmacological group.The Molecular Weight of Nystatin is 926.00. Its pKa is 4.5, 8.64.
Contraindications
Nystatin
Effects
The signs and symptoms that are produced after the acute overdosage of Nystatin include Nephrotoxicity.The symptomatic adverse reactions produced by Nystatin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Diarrhea, Abdominal pain, Rashes, Urticaria, Skin irritation, Contact dermatitis, Stevens Johnson syndrome, Contact dermatitis, rashes.
Indications
Nystatin is primarily indicated in conditions like Candidiasis, Fungal infection, Intestinal candidiasis, Oral and perioral fungal infections, and can also be given in adjunctive therapy as an alternative drug of choice in Vaginal infections.
Interactions
No data regarding the interactions of Nystatin was found.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab, Drops, Pessaries, Oint, Cream Store Below 40°C. Do not Freeze. Store in a well closed container. Protect from Sunlight.
Warnings
Nystatin should be used cautiously in patients with paraben hypersensitivity and in diabetes mellitus patients. It is classified as pregnancy category C drug and should be used during pregnancy only if clearly needed.
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