NORADRIN NOREPINE

Dose: 0.114 to 0.171 ug/kg/min
Single Dose: 0.14 (0.1425)
Frequency: As recommended.
Route: IV Inf
Instructions: Adjusted according to B.P. response

Dose: 0.1 to 0.2 ug/kg.min
Single Dose: 0.15 (0.15)
Frequency: As recommended.
Route: IV Infusion
Instructions: Maintenance , As required

Dose: 0.1 to 0.2 ug/kg.min
Single Dose: 0.15 (0.15)
Frequency: As recommended.
Route: IV Infusion
Instructions: Maintenance , As required

Noradrenaline (Acid Tartrate) also known as Norepinephrine. . It is of Natural origin and belongs to Catecholamine. It belongs to Alpha adrenergic agonist pharmacological group on the basis of mechanism of action and also classified in Drugs used in Shock and Vasoconstrictor pharmacological group.The Molecular Weight of Noradrenaline (Acid Tartrate) is 337.30. Its pKa is 8.6, 9.8, 12.

Noradrenaline (Acid Tartrate) is contraindicated in conditions like Hypertension,Hyperthyroidism,Myocardial infarction,Ischaemic heart disease.

The severe or irreversible adverse effects of Noradrenaline (Acid Tartrate), which give rise to further complications include Gangrene, Sloughing, Local necrosis.Noradrenaline (Acid Tartrate) produces potentially life-threatening effects which include Cerebral hemorrhage, Pulmonary edema, Hypertension. which are responsible for the discontinuation of Noradrenaline (Acid Tartrate) therapy.The signs and symptoms that are produced after the acute overdosage of Noradrenaline (Acid Tartrate) include Sweating, Headache, Pallor, Severe hypertension, Retrosternal pain, Photophobia.The symptomatic adverse reactions produced by Noradrenaline (Acid Tartrate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Anxiety, Palpitation, Bradycardia.

Noradrenaline (Acid Tartrate) is primarily indicated in conditions like Acid-related dyspepsia, Cardiac arrest, Hypotension, Shock, and can also be given in adjunctive therapy as an alternative drug of choice in Local anaesthesia, Local anaesthetic.

Noradrenaline (Acid Tartrate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAmitriptyline (HCl)AmoxapineChlorothiazideChlorthalidoneClomipramine (HCl)ClozapineCocaineDebrisoquine (Sulphate)Desmopressin (Acetate)DigoxinDopamine (HCl)Dopexamine (HCl)Doxepin (HCl)EphedrineGuanethidineGuanethidine work by depleting catecholamines stores from adrenergic nerve endings enhance pharmacologic effect of noradrenaline while decrease its hypotensive effect.ModerateMonitoring of blood pressure and heart rate is must if this combination is used.In hypertensive patients noradrenaline is used with caution.HalothaneImipramine (HCl)LypressinMannitolMethyldopaMethyldopa enhanced the pressor effects of norepinephrine results in hypertension.ModerateClosely monitor the blood pressure of patient regularly. If hypertension develop, dicontinue the norepinephrine.PiretanideProtriptyline (HCl)TerlipressinTolazoline (HCl)Tramadol (HCl)VasopressinVecuronium (Br) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Inj Store at room temperature. Protect from Sunlight.

Infuse noradrenaline into large vein to avoid necrosis & sloughing. Dangerously high B.P may produced with overdoses, so monitor B.P after every two min. from the time of administration until desired B.P is obtained, then after every five min. administration is to be continued. Its use is not a substitute for the replacement of blood, plasma, fluid & electrolytes. .