Nizatidine

Nizatidine is oral H-2-receptor antagonist similar to cimetidine, famotidine, and ranitidine. It currently is indicated for gastroesophageal reflux disease (GERD), short-term and maintenance treatment of duodenal ulcer, and short-term treatment of active benign gastric ulcer. It was originally approved by the FDA in April 1988. It competitively inhibits the binding of histamine to the H-2-receptors on the gastric basolateral membrane of parietal cells, reducing basal and nocturnal gastric acid secretions. The drug also decreases the gastric acid response to stimuli such as food, caffeine, insulin, betazole, or pentagastrin. It may aid in gastromucosal healing, and it may protect the mucosa from the irritant effects caused by aspirin and nonsteroidal antiinflammatory agents..

Brands
SIMKO
Adult Dose
Dose: 150 mg
Single Dose: 150 (150)
Frequency: 12 hourly
Route: PO
Instructions:
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Synthetic origin and belongs to Ethenediamine. It belongs to H2 and 5HT antagonist pharmacological group on the basis of mechanism of action and also classified in Histamine (H-2) Antagonists pharmacological group.The Molecular Weight of Nizatidine is 331.50.
Contraindications
Nizatidine
Effects
The signs and symptoms that are produced after the acute overdosage of Nizatidine include Diarrhea, Emesis, Miosis, Lacrimation, Salivation.The symptomatic adverse reactions produced by Nizatidine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Urticaria, SweatingX, SomnolenceX.
Indications
Nizatidine is primarily indicated in conditions like Benign gastric ulcer, Benign gastric, duodenal or NSAID-associated ulceration, Duodenal ulcer, Gastro-oesophageal reflux disease, Peptic ulcer, Reflux oesophagitis, and can also be given in adjunctive therapy as an alternative drug of choice in Dyspepsia.
Interactions
Nizatidine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAspirinIn patients given very high doses (3,900 mg) of aspirin daily, increases in serum salicylate levels were seen when nizatidine, 150 mg b.i.d., was administered concurrently.CeftibutenItraconazoleNizatidine may interfere with the absorption of Itraconazole.KetoconazoleNizatidine may interfere with the absorption of Ketoconazole. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Elevations of SGPT and SGOT
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Caps Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Nizatidine should be used with caution in patients with impaired kidney or liver function. Intravenous injection should be given slowly and intravenous infusion is recommended in patients with cardiovascular impairment.
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