Nitrazepam

Nitrazepam is a 1,4-benzodiazipine. A substituent in the 7th position such as halogen or a nitro group is required for its sedative-hypnotic activity. It has depressant action on CNS. Used in the treatment of insomnia. Nitrazepam is not available in any combination preparations.Nitrazepam is administered orally. May cause dependence even in therapeutic dosage.

Brands
MOGADON MOGADON
Adult Dose
Dose: 5 to 10 mg
Single Dose: 7.5 (7.5)
Frequency: As recommended.
Route: PO
Instructions: At bed time
Neonatal
Dose: 0.25 mg/kg
Single Dose: 0.25 (0.25)
Frequency: 12 hourly
Route: Oral
Instructions: -
Paedriatic
Dose: 0.25 mg/kg
Single Dose: 0.25 (0.25)
Frequency: 12 hourly
Route: Oral
Instructions: -
Characteristics
. It is of Natural origin and belongs to Benzodiazepine. It belongs to Chloride Channel Potentiater (GABA operated) pharmacological group on the basis of mechanism of action and also classified in Anti-epileptic Agent pharmacological group.The Molecular Weight of Nitrazepam is 281.30. Its pKa is 3.2, 10.8.
Contraindications
Nitrazepam
Effects
The severe or irreversible adverse effects of Nitrazepam, which give rise to further complications include Aggression, Anxiety, Aggression.Nitrazepam produces potentially life-threatening effects which include Anaphylaxis. which are responsible for the discontinuation of Nitrazepam therapy.The signs and symptoms that are produced after the acute overdosage of Nitrazepam include Drowsiness, Ataxia, Sedation, Dysarthria.The symptomatic adverse reactions produced by Nitrazepam are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Constipation, Blurred vision, VertigoX, Hypotension, Loss of libido, Slurred speech, Respiratory depression, Hypotension.
Indications
Nitrazepam is primarily indicated in conditions like Warts.
Interactions
No data regarding the interactions of Nitrazepam was found.
Interfrence
False +ve result in the colorimetric method of Baer.
Risks
Drug should not be given to Pregnant Mothers, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab, Susp Store at room temperature, Below 30°C. Protect from Sunlight.
Warnings
Perform periodic blood counts and liver function tests during long term therapy. Nitrazepam should be used with caution in patients if increased salivation cause respiratory difficulty, because it may produce an increase in salivation. Give least amount of drug to patients in whom depression accompanies anxiety and suicidal tendencies may be present. It should be used with caution (if it contains tartrazine) in patients with aspirin hypersensitivity because it may cause allergic reaction (including bronchial asthma). It should be used with caution in patients with porphyria.
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