Nimodipine

Nimodipine is oral calcium-channel blocking agent. Because of its selectivity for cerebral arterioles, Nimodipine is used to treat subarachnoid hemorrhage (SAH) rather than hypertension, as other dihydropyridines are used. It has negligible effects on AV node conduction, similar to other members of the dihydropyridine subgroup. It also has shown efficacy in the prophylaxis of migraine. It was approved by the FDA in December 1988. Like other calcium-channel antagonists, it inhibits the influx of extracellular calcium through myocardial and vascular membrane pores that are selective for specific ions. Serum calcium levels remain unchanged. Although the exact mechanism is unknown, Nimodipine is believed that it inhibits this influx by binding to specific receptors on the cell membrane in or near the calcium channel., which causes a conformational change in the channel, making it unavailable for opening. The decrease in intracellular calcium inhibits the contractile processes of smooth muscle cells, causing dilation of the arteries and increased oxygen delivery to the area being supplied.

Brands
NORTOLAN NORTOLAN NIMOTOP NIMOTOP NIDOPIN NIMODEN BREDIN BREDIN NIMODEX DURANIM NIMOPRO NIMOVAS NIMOVAS NIMOVAS NIMOTIN
Adult Dose
Dose: 0.5 to 1 mg/hr
Single Dose: 0.75 (0.75)
Frequency: As recommended.
Route: IV Inf
Instructions: For first 2 hrs. then 2mg/hr 5-14 days
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Synthetic origin and belongs to Dihydropyridine. It belongs to Calcium L-channel antagonist pharmacological group on the basis of mechanism of action. The Molecular Weight of Nimodipine is 418.50.
Contraindications
Nimodipine is contraindicated in conditions like Hypotension.
Effects
The signs and symptoms that are produced after the acute overdosage of Nimodipine include Tachycardia.The symptomatic adverse reactions produced by Nimodipine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Fatigue, Nausea, Constipation, Rashes, GI upset, Hypotension, Flushing, Joint pain.
Indications
Nimodipine is primarily indicated in conditions like Cerebral impairment, Premedication before surgery, Prevention of xerostomia, Subarachnoid haemorrhage.
Interactions
Nimodipine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCaffeineDigoxinPhenytoin (Na)QuinidineVORICONAZOLEVoriconazole may increase the serum concentration of nimodipine by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Caps Store Below 40°C. Protect from Sunlight and Heat.
Warnings
Nimodipine should be used only if clearly needed during pregnancy. It should be used with caution in patients with any pre-existing heart disease, lung disease or if have any allergy.
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